To compare the accuracy of spinal magnetic resonance myelography (MRM) and CT myelography (CTM) in the detection of spontaneous intracranial hypotension (SIH). The clinica data of SIH patients at the Neurology Department of Zhongshan Hospital Affiliated to Fudan University between June 2021 and August 2023 were prospectively collected. MRM was performed first, CTM, followed by CTM. CTM results were used as the gold standard to verify the consistency of MRM and CTM examination, and the diagnostic results of epidural cerebrospinal fluid accumulation were observed. The abnormal accumulation of cerebrospinal fluid(CSF) was further recorded in 4 parts, namely, the posterior part of the cervical vertebra, the nerve root walking area, the side of the vertebra and the side of the ribs. Kappa consistency test was used to compare and analyze the evaluation results of the two examination methods. A total of 31 patients were included in the study, including 13 males and 18 females, aged (40.7±7.0) years. The positive rate of CSF leakage detected by MRM was 93.5%(29 cases), and that detected by CTM was 87.1% (27 cases). Kappa consistency analysis showed that there was a high consistency between MRM and CTM (Kappa=0.635, <0.001). MRM had good consistency with CTM in detecting CSF accumulation along the nerve root area and paracostal area (Kappa values were 0.469 and 0.652, respectively). MRM had relatively low consistency with CTM in detecting CSF accumulation behind the C vertebrae and in the paravertebral area (Kappa values were 0.241 and 0.271, respectively), but the former had a higher sensitivity (0.833, 95%:0.436-0.991), and the latter had a higher specificity (0.963, 95%:0.817-0.998). MRM has a comparable value to CTM in diagnosing epidural CSF accumulation in SIH patients, with good consistency. Besides, it is non-invasive and radiation-free, and may be a suitable alternative method for the initial assessment of SIH patients.
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http://dx.doi.org/10.3760/cma.j.cn112137-20241210-02796 | DOI Listing |
J Phys Chem A
March 2025
State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.
Identifying atomic-level mechanisms in elemental chemical reactions is crucial for understanding complex reaction processes. This study focuses on the typical multichannel H + NHCl reaction, which plays a significant role in environmental science. High-level ab initio calculations determined seven distinct reaction pathways, leading to three product channels: H + NHCl, HCl + NH, and Cl + NH.
View Article and Find Full Text PDFAcad Radiol
March 2025
Department of Nuclear Medicine, Beijing Luhe Hospital, Capital Medical University, Xinhua Road 82, Tong Zhou District, 101199 Beijing, China.
Rationale And Objectives: The objective of this research is to carry out a systematic review and meta-analysis to detect the diagnostic efficacy of 68Ga-FAPI Positron Emission Tomography (PET) Computed Tomography/Magnetic Resonance (CT/MR) in total of the lesions as well as different aspects of metastasis in individuals with ovarian cancers (OC).
Materials And Methods: The PubMed, Embase, Cochrane library, and Web of Science databases were thoroughly searched until the cut-off date of July 23, 2024. The assessment of 68Ga-FAPI PET CT/MR of OC was presented by the included studies.
J Am Coll Cardiol
March 2025
Cedars Sinai Medical Center, Los Angeles, California, USA. Electronic address:
This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic valve failure in a practical, imaging directed context for TAVR.
View Article and Find Full Text PDFAnal Chim Acta
May 2025
State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, Guangxi University, Nanning, Guangxi, 530004, PR China; College of Life Science and Technology, Guangxi University, Nanning, Guangxi, 530004, PR China; Medical College of Guangxi University, Guangxi University, Nanning, Guangxi, 530004, PR China; Center for Instrumental Analysis, Guangxi University, Nanning, Guangxi, 530004, PR China. Electronic address:
Tryptophan (Trp) is an essential amino acid obtained from human diet. It is involved not only in de novo biosynthesis of proteins but also in complex metabolic pathways. Redox transformation of tryptophan is under-explored in comparison with kynurenine, serotonin and indole pyruvate pathways.
View Article and Find Full Text PDFJ Genet Eng Biotechnol
March 2025
Department of Chemistry, College of Sciences, Jouf University, PO Box 72341, Sakaka, Saudi Arabia.
Focus of this study is on the use of the hydrazone compound (3) (N-(4-bromobenzylidene)-4-(1H-indol-3-yl) butane hydrazide), which was previously prepared from the reaction of the compound p-bromobenzaldehyde with the corresponding hydrazide (2), as an intermediate compound for the synthesis of azetidine, thiazolidine, tetrazole, oxadiazole and phthalazine heterocyclic compounds through its reaction with some cyclic reagents and catalysts such as chloro acetyl chloride, thioglycolic acid, sodium-azid, lead dioxide and Hydrogen chloride gas. The prepared compounds were characterized using physical properties and also spectroscopic methods such as infrared spectroscopy, nuclear magnetic resonance spectra of the proton and the isotope of carbon as well as mass spectrometry, which accurately identified the proposed structures of the prepared compounds. The identity of the prepared compounds was determined using physical and spectroscopic properties, where infrared and HNMR spectroscopy of the proton as well as carbon were used in addition to using mass spectrometry to verify the validity of the prepared structures.
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