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Identification and Experimental Validation of Biomarkers Related to MiR-125a-5p in Chronic Obstructive Pulmonary Disease.
Int J Chron Obstruct Pulmon Dis
March 2025
Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China.
Purpose: The miR-125a-5p has been reported influence the development of lung cancer, however, the link between it and chronic obstructive pulmonary disease (COPD) is still not well understood. Hence, this study was designed to investigate the molecular pathway by which miR-125a-5p related biomarkers were involved in COPD.
Patients And Methods: The differentially expressed genes (DEGs) and module genes related to COPD in GSE100153 were screened out by differential analysis and weighted gene co-expression network analysis, respectively.
Monte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia.
Front Cell Infect Microbiol
March 2025
Department of Pharmacy, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.
Objective: This study aimed to predict and evaluate the efficacy of various polymyxin B dosing regimens for Gram-negative bacteremia using Monte Carlo simulation, with a specific focus on assessing the efficacy in patients receiving continuous renal replacement therapy (CRRT). The goal was to optimize clinical dosing regimens and guide rational polymyxin B use in practice.
Methods: A total of 1,939 Gram-negative bacterial strains were analyzed, collected between April 2019 and December 2021 through the China Bloodstream Gram-negative Pathogens Antimicrobial Resistance and Virulence Surveillance Network (CARVIS-NET).
Novel Insights into the Therapeutic Effect of Amentoflavone Against Infection by Blocking the Activity of Aerolysin.
Int J Mol Sci
March 2025
Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
() is an opportunistic and foodborne pathogen widely spread in the environments, particularly aquatic environments. Diseases caused by in freshwater aquaculture result in huge economic losses every year. The increasing emergence of antibiotic resistance has limited the application of antibiotics in aquaculture.
View Article and Find Full Text PDFGPCRVS - AI-driven Decision Support System for GPCR Virtual Screening.
Int J Mol Sci
February 2025
University of Warsaw, Faculty of Chemistry, 1 Pasteur St, 02-093 Warsaw, Poland.
G protein-coupled receptors (GPCRs) constitute the largest and most frequently used family of molecular drug targets. The simplicity of GPCR drug design results from their common seven-transmembrane-helix topology and well-understood signaling pathways. GPCRs are extremely sensitive to slight changes in the chemical structure of compounds, which allows for the reliable design of highly selective and specific drugs.
View Article and Find Full Text PDFPredictions of the Biological Effects of the Main Components of Tarragon Essential Oil.
Int J Mol Sci
February 2025
Department of Biology, West University of Timisoara, 16 Pestalozzi, 300115 Timișoara, Romania.
/(tarragon) is a perennial plant used in traditional medicine and the food industry. The plant is known to have beneficial effects on health, such as antibacterial, antifungal, antiseptic, carminative, anti-inflammatory, antipyretic, anthelmintic, etc. In this study, the compounds present in the highest concentrations in the essential oils obtained by different extraction methods from tarragon found on the Romanian market were identified by gas chromatography-mass spectrometry.
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