Impaction of third molars and localized cancer of the oral cavity: a simple occasional finding? A retrospective case series and literature review.

J Stomatol Oral Maxillofac Surg

Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.

Published: March 2025

Objectives: The aim of this study is to analyze, through a literature review and the description of four clinical cases, whether prolonged tooth impaction may represent a trigger for the onset of oral carcinoma.

Materials E Methods: In this report, four cases of patients needing the extraction of third molars in complete mucosal or bone impaction are described, which, due to the presence of an unusual radiographic and/or clinical aspect, were found to represent cases of oral carcinomas on histologic analysis. Patients were then referred to the ENT department for further care. A review of the literature has been performed as well.

Results: Literature analysis revealed the presence of only few case reports on the topic, suggesting therefore a lack of evidence on the correlation between tooth impaction and the onset of oral carcinomas.

Conclusions: Further studies are needed in order to give valid hypotheses. The concept of inflammation, that is at the base of oral carcinogenesis mechanism and tooth-related pathologies, such as pericoronitis, may be a common substrate to link these two phenomena.

Clinical Relevance: A thorough analysis of the radiographic and clinical signs is strongly recommended prior and during surgical procedures, such as tooth extraction.

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http://dx.doi.org/10.1016/j.jormas.2025.102307DOI Listing

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