Toxoplasma gondii is a coccidian parasite capable of infecting humans and other warm-blooded animals, with approximately 30% of the world's population chronically infected. Workers who handle animals occupationally, such as veterinarians in small-animal practices, are at a higher risk of infection. Common risk factors among these workers include contact with cats and other animals in a clinical setting. For this reason, this study aimed to determine the seroprevalence of anti-T. gondii immunoglobulin (Ig)G and IgM antibodies among small-animal veterinary personnel in Veracruz, Mexico. Blood samples were collected from 133 healthy individuals and examined using an enzyme-linked immunosorbent assay. A detailed survey on work activities was conducted. The findings showed a 2.2% positive rate for specific anti-T. gondii IgG antibodies and a 0% rate for anti-T. gondii IgM antibodies, which underscores the need for further preventive educational programs to reduce exposure to T. gondii infection in this population.
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http://dx.doi.org/10.1645/24-84R2 | DOI Listing |
J Parasitol
March 2025
Facultad de Bioanálisis, Universidad Veracruzana, Veracruz, México, 91700.
Toxoplasma gondii is a coccidian parasite capable of infecting humans and other warm-blooded animals, with approximately 30% of the world's population chronically infected. Workers who handle animals occupationally, such as veterinarians in small-animal practices, are at a higher risk of infection. Common risk factors among these workers include contact with cats and other animals in a clinical setting.
View Article and Find Full Text PDFJ Agric Food Chem
March 2025
Institute of Epidemic Prevention & Control, National Center of Technologies Innovation for Pigs, Rongchang 402460, China.
A novel series of quinazolin-4(3)-one derivatives were synthesized using a hybridization strategy that combined the quinazolin-4(3)-one scaffold, the diarylether fragment, and the piperazine ring. The activity evaluation of these compounds against demonstrated that most of this series of compounds showed moderate to good effectiveness, with IC values ranging from 5.94 to 102.
View Article and Find Full Text PDFBiomolecules
February 2025
Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Toxoplasmosis is a significant zoonotic parasitic disease. Currently, there is no effective vaccine available to prevent human infection, and treatment primarily relies on chemotherapy. However, the lack of specific therapeutic agents and the limitations of existing drugs highlight the urgent need for novel, safe, and effective anti- () medications.
View Article and Find Full Text PDFParasit Vectors
February 2025
Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.
Background: Toxoplasma gondii (T. gondii) is one of the most prevalent parasites worldwide. At present, the majority of drugs used for the treatment of toxoplasmosis target the tachyzoite stage of T.
View Article and Find Full Text PDFChem Biol Interact
March 2025
Laboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. Electronic address:
Owing to the lack of efficient therapy and emerging resistance strains, toxoplasmosis affects about one-third of the world's population. Also, pregnancy-related infection can cause vertical transmission and result in fetal death. Despite the global efforts to combat Toxoplasma gondii infection, conventional therapies have been associated with serious side effects.
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