Purpose: Chronic kidney disease (CKD) affects pulmonary and cardiovascular systems. This study evaluates functional and pulmonary capacity in pediatric patients with CKD stages 1 to 5.
Methods: Medical records of 30 pediatric CKD patients (stages 1-5) from December 2019 to February 2021 were analyzed. Functional capacity was assessed with the 6-minute walk test and spirometry measured pulmonary function. Data on body mass index z scores, height z scores, and CKD etiology (congenital anomalies of the kidney and urinary tract, glomerulonephritis, or others) were included. Correlation and regression analyses evaluated relationships between CKD severity, pulmonary function, and functional capacity.
Results: Functional capacity worsened with CKD progression, with stage 5 patients showing the lowest 6-minute walk test distances (384 [71] m). Pulmonary function tests revealed lower forced expiratory volume in 1 second and peak expiratory flow values compared with healthy peers (P = .04, P < .001). Restrictive patterns were observed in early CKD, with obstructive changes in advanced stages. Positive correlations were noted between 6-minute walk test and forced expiratory volume in 1 second (r = .42) and peak expiratory flow (r = .48). Height z score emerged as an independent predictor of pulmonary outcomes.
Conclusions: CKD progressively impairs functional and pulmonary capacity in children, especially in advanced stages. These findings underline the importance of comprehensive care focusing on physical and respiratory health. Prospective studies are needed to validate these results and develop targeted interventions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1123/pes.2024-0128 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-performance magnesium organic batteries using renewable biomolecule-based cathode.
Chemistry
March 2025
Chongqing University, College of Materials Science and Engineering, CHINA.
Rechargeable magnesium batteries (RMBs) exhibit significant potential in large-scale energy storage due to their features of high volumetric capacity, resistance to dendrite formation, and abundant magnesium resources. However, the high polarity of divalent Mg2+ ions results in sluggish diffusion kinetics in conventional inorganic cathode materials, adversely affecting reversible capacity and rate performance. Organic materials such as pyrene-4,5,9,10-tetrone (PTO) and 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA), achieve rapid and reversible intercalation of magnesium ions through carbonyl enolization, but these materials are challenged by high cost, complex preparation, and poor environmental friendliness.
View Article and Find Full Text PDFTeleost IgM+ plasma-like cells: beyond antibody secretion.
J Immunol
January 2025
Biotechnology Department, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Upon antigen encounter, B cells start a differentiation process toward antibody-secreting cells (ASCs), initially plasmablasts, and eventually long-lived plasma cells. All these ASCs specialize in secreting important amounts of antibodies and usually lose other functionalities of naïve B cells. This differentiation process is scarcely characterized in teleost fish, in which B cells have been shown to share many functional and phenotypic characteristics of mammalian B1 innate subsets.
View Article and Find Full Text PDFEffects of PARP1 inhibitor PJ-34 on TGFα, IL-6, and IL-1β levels in diabetic nephropathy.
J Immunol
February 2025
Orthopedics Department, Central Hospital of Ezhou, Ezhou, China.
Diabetic nephropathy is a severe chronic complication characterized by cytotoxicity, inflammation, and fibrosis, ultimately leading to renal failure. This study systematically investigated the effects of the PARP1 inhibitor PJ-34 on high glucose-induced cytotoxicity, inflammation, and fibrosis in HK-2 cells, as well as its improvement on neuropathic pain response and transforming growth factor β (TGFβ) expression in a type 1 diabetes mellitus diabetic nephropathy mouse model. Through cellular and animal experiments, we observed that PJ-34 significantly enhanced the proliferative capacity of cells damaged by high glucose, reduced apoptosis, and decreased the release of proinflammatory factors TGFα, interleukin-6, and interleukin-1β.
View Article and Find Full Text PDFInnateness transcriptome gradients characterize mouse T lymphocyte populations.
J Immunol
February 2025
La Jolla Institute for Immunology, La Jolla, CA, United States.
A fundamental dichotomy in lymphocytes separates adaptive T and B lymphocytes, with clonally expressed antigen receptors, from innate lymphocytes, which carry out more rapid responses. Some T cell populations, however, are intermediates between these 2 poles, with the capacity to respond rapidly through T cell receptor activation or by cytokine stimulation. Here, using publicly available datasets, we constructed linear mixed models that not only define a gradient of innate gene expression in common for mouse innate-like T cells, but also are applicable to other mouse T lymphoid populations.
View Article and Find Full Text PDFGene-modified NK cells expressing CD64 and preloaded with HIV-specific BNAbs target autologous HIV-1-infected CD4+ T cells by ADCC.
J Immunol
February 2025
HIV Immunopathogenesis Laboratory, BEAT-HIV Delaney Collaboratory, Wistar Institute, Philadelphia, PA, United States.
Natural killer (NK) cells can efficiently mediate antibody-dependent cellular cytotoxicity (ADCC) of antibody coated target cells via the low-affinity Fc-receptor, CD16, but cannot retain antibodies over time. To increase antibody retention and facilitate targeted ADCC, we genetically modified human NK cells with the high-affinity Fc receptor, CD64, so that we could preload them with HIV-specific broadly neutralizing antibodies (BNAbs) and enhance their capacity to target HIV-infected cells via ADCC. Purified NK cells from the peripheral blood of control donors or persons living with HIV were activated with interleukin (IL)-2/IL-15/IL-21 cytokines and transduced with a lentivirus encoding CD64.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!