Although guideline-directed medical therapy (GDMT) is an evidence-based, proven approach to manage chronic kidney disease and type 2 diabetes (CKD + T2DM), adherence is low and multifactorial. Opportunities exist to improve care delivery, thus delaying disease progression, avoiding unnecessary costs, and potentially improving quality of life for patients both diagnosed and yet to be diagnosed.
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Prognostic Implications of Guideline-Directed Medical Therapy for Heart Failure in Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis.
Diagnostics (Basel)
March 2025
1st Department of Cardiology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Randomized evidence on the role of heart failure guideline-directed medical therapy for patients with functional mitral regurgitation (FMR) is lacking. The present meta-analysis sought to investigate the prognostic impact of different pharmacotherapy categories recommended in heart failure on subjects with FMR. A systematic literature review was conducted to identify studies reporting the association of renin angiotensin system inhibitors (RASi), beta-blockers (BB), and mineralocorticoid receptor antagonists (MRA) with outcomes in FMR.
View Article and Find Full Text PDFDo Potassium Binders Block Both the Benefits and the Risks of Mineralocorticoid Receptor Antagonists in Heart Failure?: The Four Anti-Aldosterone Myths.
J Am Coll Cardiol
March 2025
Baylor Heart and Vascular Institute, Dallas, Texas, USA; Imperial College, London, United Kingdom. Electronic address:
Novel device therapies in heart failure: focus on patient selection.
Front Cardiovasc Med
February 2025
Department of Cardiology, Lenox Hill Hospital, Northwell Health, New York, NY, United States.
The increasing prevalence of heart failure (HF) has led to advancements in therapeutic strategies, including the development of new pharmacological treatments and the expansion of guideline recommendations across the spectrum of left ventricular ejection fractions. Despite these advancements, the full benefits of guideline-directed medical therapy (GDMT) are often limited by various barriers that result in incomplete implementation or suboptimal responses. For patients who cannot tolerate or only partially respond to GDMT, therapeutic options remain limited.
View Article and Find Full Text PDFPhysical activity levels and associated biopsychosocial characteristics among attendees to exercise-based cardiac rehabilitation.
Scand Cardiovasc J
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Department of Women's and Children's Health, Physiotherapy, Uppsala University, Uppsala, Sweden.
Aim: Exercise-based cardiac rehabilitation (exCR) reduces morbidity and mortality after acute coronary syndrome (ACS). Little is known about physical activity levels at exCR program completion and associated demographic, medical, and psychosocial factors.
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Performance and opportunity: retrospective cohort study of general medicine heart failure management.
Intern Med J
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Department of General Medicine, Alfred Health, Melbourne, Victoria, Australia.
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