Background: Improving family function and resilience among cancer caregivers is a vital clinical concern requiring thorough research. Psychosocial interventions are expected to enhance family function and strengthen resilience; however, the outcomes can differ significantly, highlighting the necessity for further investigation.
Objectives: This study aimed to evaluate the comparative effectiveness of psychosocial interventions in enhancing family function and resilience among caregivers of cancer patients based on data derived from randomized controlled trials.
Methods: A systematic review was performed by searching 6 electronic databases and clinical trial registries until July 12, 2024. Pairwise and network meta-analyses (NMA) were performed using the network package in STATA 16.
Results: This review identified 12 studies with a total of 1162 participants. The pairwise meta-analysis revealed a significant positive impact of psychosocial interventions on family function: standardized mean difference (SMD), 1.34; 95% confidence interval [CI], 0.16-2.52. NMA showed family interaction approaches (SMD, 0.69; 95% CI, 0.22-1.15) and psychoeducation interventions (SMD, 0.66; 95% CI, 0.24-1.08) both led to improvements in family function. However, neither the pairwise meta-analysis nor the NMA revealed the positive effects of psychosocial interventions on resilience.
Conclusion: Evidence suggests that psychosocial interventions can moderately improve family function. Among the various interventions explored, the family interactions demonstrated the most significant potential for effectiveness. However, resilience meta-analyses have not supported our psychosocial intervention recommendations.
Implications For Practice: This study offers valuable insights for nursing practice, emphasizing the need for nurses to consider the relationships and resources available within the families of cancer patients while providing care.
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http://dx.doi.org/10.1097/NCC.0000000000001476 | DOI Listing |
J Cell Mol Med
March 2025
Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Joubert syndrome (JS) is a rare neurodevelopmental disorder associated with mutations in genes involved in ciliary function. Germline variants in CPLANE1 have been implicated in JS. In this study, we investigated a family with three adverse pregnancies characterised by fetal malformations consistent with JS.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with different risk factors, including family history. This study aimed to explore association between a family history of chronic airway disease and features and outcomes of COPD.
Methods: Participants were obtained from the RealDTC study between December 2016 and December 2022.
J Am Coll Cardiol
March 2025
Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, Quebec, Canada. Electronic address:
Background: The clinical impact of genetic testing in a contemporary real-life cohort of patients with heritable cardiomyopathies or arrhythmias is not well defined. Additionally, the genetic spectrum of these conditions in the French-Canadian population is unknown, and interpretation of genetic variants can be challenging because of a known founder effect.
Objectives: This study sought to evaluate the clinical utility of arrhythmia and cardiomyopathy genetic testing and assess the utility of allele frequency data from a local reference population.
J Am Coll Cardiol
March 2025
Ciccarone Center for Prevention of Cardiovascular Disease, Johns Hopkins Medicine, Baltimore, Maryland, USA; American Heart Association Tobacco Regulation and Addiction Center, Dallas, Texas, USA. Electronic address:
Background: Cigarette smoking is a strong risk factor for cardiovascular harm.
Objectives: The study sought to explore the detailed relationships between smoking intensity, pack-years, and time since cessation with inflammation, thrombosis, and subclinical atherosclerosis markers of cardiovascular harm.
Methods: We included 182,364 participants (mean age 58.
J Genet Eng Biotechnol
March 2025
Faculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet 3100, Bangladesh; Department of Molecular Biology and Genetic Engineering, Sylhet Agricultural University, Sylhet 3100, Bangladesh. Electronic address:
One of the largest and most significant transcription factor gene families in plants is the SQUAMOSA promoter binding protein (SBP) gene family and they perform critical regulatory roles in floral enhancement, fruit development, and stress resistance. The SBP protein family (also known as SPL) has not yet been thoroughly studied in the staple fruit crop, banana. A perennial monocot plant, banana is essential for ensuring food and nutrition security.
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