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Will Stub1 Be the Next Target for Pulmonary Hypertension Therapy Development?
Am J Respir Cell Mol Biol
March 2025
Binghamton University School of Pharmacy and Pharmaceutical Sciences, Pharmaceutical Sciences, Johnson City, New York, United States;
Purpose Of Review: Late-onset genetic cerebellar ataxias are clinically heterogenous with variable phenotypes. Several of these conditions are commonly associated with dementia. Recognition of the relationship between ataxia and dementia can guide clinical genetic evaluation.
View Article and Find Full Text PDFElucidating cellular interactome of chikungunya virus identifies host dependency factors.
Virol Sin
August 2023
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250013, China; Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China. Electronic address:
Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain. To better understand how CHIKV rewires the host cell and usurps host cell functions, we generated a systematic CHIKV-human protein-protein interaction map and revealed several novel connections that will inform further mechanistic studies. One of these novel interactions, between the viral protein E1 and STIP1 homology and U-box containing protein 1 (STUB1), was found to mediate ubiquitination of E1 and degrade E1 through the proteasome.
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- * Genetic analysis confirmed the presence of a STUB1 mutation, linking her condition to SCAR-16, a type of STUB1-associated cerebellar ataxia.
- * The report aims to educate radiologists on the MRI and CT features of this condition and how to distinguish between SCAR-16 and SCA-48 types of STUB1-associated cerebellar ataxia.
Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
J Med Chem
July 2022
Quantitative Biosciences, MSD, 8 Biomedical Grove, Singapore 138665.
Recent evidence suggests that deletion of STUB1─a pivotal negative regulator of interferon-γ sensing─may potentially clear malignant cells. However, current studies rely primarily on genetic approaches, as pharmacological inhibitors of STUB1 are lacking. Identifying a tool compound will be a step toward validating the target in a broader therapeutic sense.
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