Objectives: Despite growing evidence linking adverse childhood experiences (ACEs) with physical health conditions such as obesity and hypertension, research in low- and middle-income countries (LMICs), including India, remains limited. This study aims to examine the relationship between ACE exposure and the risk of overweight/obesity and hypertension among young adults in Delhi-NCR, India.
Methods: The present cross-sectional study involved 1702 young adults of both sexes. Participants were recruited from two universities in Delhi-NCR, India. ACEs were measured using the ACE-International questionnaire (ACE-IQ), while anthropometric (weight, height, waist circumference, and hip circumference) and blood pressure parameters were assessed using standard protocols.
Results: The prevalence of overweight/obesity increased with higher ACE categories, from 38% among participants with no ACEs to 49.7% among those with ≥ 4 ACEs (p = 0.006). Linear regression showed a significant positive association between ACE scores and BMI (β = 0.182, p = 0.004), waist circumference (WC; β = 0.351, p = 0.022), and waist-to-height ratio (WHtR; β = 0.002, p = 0.026). Odds ratio analysis revealed that participants with 3 or more ACEs had increased odds of being overweight/obese compared to unexposed individuals. No consistent associations were found between ACE exposure and blood pressure parameters. Among specific ACE domains, household mental illness was associated with higher odds of both general and central obesity, and bullying showed the highest odds for overweight/obesity.
Conclusions: ACE-exposed young adults may be at a higher risk of overweight/obesity; however, the risk of hypertension may not be immediate. Early intervention may help offset the risk of obesity and related disorders among ACE-exposed youth.
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http://dx.doi.org/10.1002/ajhb.70016 | DOI Listing |
JAMA Cardiol
March 2025
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Importance: Food insecurity is associated with prevalent cardiovascular disease (CVD), but studies have been limited to cross-sectional data.
Objectives: To study whether food insecurity is associated with incident CVD and to determine whether this association varies by sex, education, or race.
Design, Setting, And Participants: This prospective cohort study was conducted among US adults without preexisting CVD participating in the CARDIA (Coronary Artery Risk Development in Young Adults) study from 2000 to August 31, 2020.
Elife
March 2025
Department of Neuroscience, Georgetown University Medical Center, Washington DC, United States.
Research on brain plasticity, particularly in the context of deafness, consistently emphasizes the reorganization of the auditory cortex. But to what extent do all individuals with deafness show the same level of reorganization? To address this question, we examined the individual differences in functional connectivity (FC) from the deprived auditory cortex. Our findings demonstrate remarkable differentiation between individuals deriving from the absence of shared auditory experiences, resulting in heightened FC variability among deaf individuals, compared to more consistent FC in the hearing group.
View Article and Find Full Text PDFClin Cancer Res
March 2025
Hospital for Sick Children, Toronto, Ontario, Canada.
Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition condition characterized by a high lifetime risk for a wide spectrum of malignancies associated with germline pathogenic/likely pathogenic (P/LP) variants in the TP53 tumor suppressor gene. Secondary malignant neoplasms are particularly common. Early cancer detection through surveillance enables early intervention and leads to improved clinical outcomes with reduced tumor-related mortality and treatment-related morbidity.
View Article and Find Full Text PDFCells
February 2025
Advanced Research Center for Geriatric and Gerontology, Akita University, Akita 010-8543, Japan.
Ageing is a major risk factor for cognitive and physical decline, but its mechanisms remain poorly understood. This study aimed to detect early cognitive and physical changes, and to analyze the pathway involved by monitoring two groups of mice: a young and an adult group. The study has identified the types of molecules involved in the hippocampus.
View Article and Find Full Text PDFCancer Biol Med
March 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas, we designed a prospective, phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL. The primary endpoint was the complete remission rate (CRR) at the end of induction (EOI).
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