Sigmund Freud's death drive tends to be invoked in ecocritical thought as a bedrock truth that explains how the drive for pleasure, mastery, and expansion within and for the human organism is inherently bound to aggression and destructiveness. But a close reading of Freud and the deviations and repetitions of drive suggests an ongoing relationship and collective alliance between life and death rather than any simple victory for destruction. This article argues that attending to the more-than-human form and force that underpins yet simultaneously resists all human projects - what Freud describes as the unanalysable "bedrock" of the death drive - offers ways of recasting the temporalities of Anthropocene imaginaries. Using the work of Catherine Malabou, Elizabeth Povinelli, Lisa Baraitser, and Édouard Glissant, this article rethinks the resistant bedrock of the death drive and its complex interweaving of life with nonlife, as a way of decentering and "de-dramatizing" formations of the human. The article suggests that attending to how things come to matter over time opens up the possibility of suspending forms of action that mortgage the existence of many human and more-than-human others to the sustaining of a certain configuration of Life only, to produce instead a time where things might be able to die in their own fashion.
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http://dx.doi.org/10.17613/wbfp0-gjt79 | DOI Listing |
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Synthetic RNA devices are engineered to control gene expression and offer great potential in both biotechnology and clinical applications. Here, we present multidisciplinary structural and biochemical data for a tetracycline (Tc)-responsive RNA device (D43) in both ligand-free and bound states, providing a structure-dynamical basis for signal transmission. Activation of self-cleavage is achieved via ligand-induced conformational and dynamical changes that stabilize the elongated bridging helix harboring the communication module, which drives proper coordination of the catalytic residues.
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View Article and Find Full Text PDFJ Nanobiotechnology
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Cancer Center, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, The 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510280, China.
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View Article and Find Full Text PDFSci Rep
March 2025
Cancer Center, Department of Thoracic Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
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View Article and Find Full Text PDFPediatr Cardiol
March 2025
Child Health Economics Unit, Centre for Health Policy, University of Melbourne, Melbourne, VIC, Australia.
Resource utilization estimates for hypoplastic left heart syndrome (HLHS) in early childhood are lacking. We linked the National Pediatric Cardiology Quality Improvement (NPC-QIC) clinical registry to the Pediatric Health Information Systems (PHIS) database to estimate hospital resource utilization for a contemporary HLHS cohort. All hospitals with both PHIS and NPC-QIC data available were eligible for inclusion.
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