Joint cartilage damage is a common condition, and various approaches exist to address these defects. Whenever conservative treatments have been exhausted or are inadequate, surgery should be taken into consideration. However, it is essential to consider the size of the damage as well as the subchondral bone involvement. As joint replacement is not an appropriate treatment for young people, a joint-preserving technique should be preferred. One option is minced cartilage implantation. This surgical procedure is appropriate for defects of around 2 cm. Studies demonstrated exceptional short-term and midterm outcomes in the knee and hip. This description of technique focuses on the implementation of AutoCart augmentation on the glenoid. The purpose of this note is to gain technical evidence of an all-arthroscopic cartilage implantation technique performed within the glenoid cavity.
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http://dx.doi.org/10.1016/j.eats.2024.103218 | DOI Listing |
Differentiation
March 2025
Department of Biological Sciences, University of Delaware, Newark, DE, USA; Department of Biomedical Engineering, University of Delaware, Newark, DE, USA. Electronic address:
Articular cartilage is an avascular tissue that allows for frictionless mobility of joints. Unfortunately, cartilage is incapable of self-repair and any damage leads to degradation in osteoarthritis (OA). Autologous chondrocyte implantation therapies are currently being used to treat focal cartilage defects caused by post-traumatic OA (PTOA).
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
March 2025
School of Aerospace Engineering, Tsinghua University, Beijing, People's Republic of China.
Myringoplasty is most commonly used to treat tympanic membrane (TM) perforation. Clinical data have shown that unexplained high-frequency (above 3 kHz) hearing loss often occurs after myringoplasty. In this paper, a finite element (FE) model of the partial external and middle ear (ME) of the human ear, which considers the actual perforation and TM implants, is developed to reveal the mechanical mechanism of high-frequency hearing loss after implantation of temporalis fascia and cartilage commonly used in myringoplasty.
View Article and Find Full Text PDFSheng Li Xue Bao
February 2025
Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China.
A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) represent a diverse family of secreted metalloproteinases, comprising 19 distinct members categorized into five groups based on their substrate specificity: proteoglycanases, procollagen N-peptidases, von Willebrand factor-cleaving protease, cartilage oligomeric matrix proteases and other proteases. Among these, ADAMTS proteoglycanases predominantly target hyalectans, pivotal components in extracellular matrix (ECM) remodeling and inflammation. Dysfunction of ADAMTS proteoglycanases disrupts the structure and function of hyalectans, thereby perturbing ECM homeostasis, resulting in reproduction disorders, including abnormal follicular development, ovulation dysfunction, impaired implantation, placentation and preterm labor.
View Article and Find Full Text PDFJ Pharm Bioallied Sci
December 2024
Dr. Nazia's Dental Care, CSI Ascension Square, Logos Juction, Kottayam, Kerala, India.
Context: Alveolar bone resorption poses a significant challenge in rehabilitating edentulous patients. Ridge augmentation materials can stimulate bone growth in deficient areas.
Aim: To evaluate the biocompatibility and osteoconductivity of maxibloc bone grafts in rabbits.
Bioact Mater
April 2025
Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
In clinical practice, repairing osteochondral defects (OCDs) is challenging because of the complex cartilage/subchondral bone structure and intricate immunological microenvironment. Here, we identify the crucial role of adaptive immunity dysfunction by revealing that an increase of T helper 17 (Th17) cells exacerbated osteochondral tissue degradation via its pro-inflammatory cytokine interleukin-17 (IL-17) in the early-stage OCDs. Next, we leveraged this adaptive immunity mechanism and combined it with regenerative signals to develop a multifunctional hydrogel system capable of simultaneously tackling immune dysfunction and regenerative deficiency.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!