A 4-month-old male infant (weight 6 kg, height 67 cm) with heart failure was diagnosed with an isolated 8.9 mm right coronary artery fistula draining into the left ventricle (LV), identified via transthoracic echocardiography and computed tomography angiography. The large, tortuous, and aneurysmal fistula was treated using a minimally invasive percoronary approach, avoiding the high risks of surgery and the challenges of percutaneous closure. A 10 mm muscular ventricular septal occluder was deployed successfully. At 3 months, imaging showed reduced LV size, excellent device positioning, and complete fistula occlusion without thrombus formation. By 6 months, optimal remodeling was confirmed. Over 10 years of follow-up, the patient's troponin I levels and electrocardiograms remained normal, with no ST-T abnormalities.
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http://dx.doi.org/10.3389/fcvm.2025.1493724 | DOI Listing |
Interdiscip Cardiovasc Thorac Surg
March 2025
Department of Cardiovascular Surgery, Anjo Kosei Hospital, Anjo, Aichi, 446-8602, Japan.
Mitral annular calcification (MAC) is a common finding, especially among the elderly or patients undergoing hemodialysis. Caseous calcification of the mitral annulus (CCMA) is a rare MAC variant with liquefied material at the calcified annulus. Surgical management of CCMA often involves wide excision and debridement, increasing the risk of perioperative stroke.
View Article and Find Full Text PDFAnn Intern Med
March 2025
The Division of Cardiology, University of Cape Town, and the SAMRC EMU on the Interaction of Cardiovascular and Infectious Diseases, Cape Town, South Africa.
Eur J Epidemiol
March 2025
Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.
Mendelian randomization (MR) is a technique which uses genetic data to uncover causal relationships between variables. With the growing availability of large-scale biobank data, there is increasing interest in elucidating nuances in these relationships using MR. Stratified MR techniques such as doubly-ranked MR (DRMR) and residual stratification MR have been developed to identify nonlinearity in causal relationships.
View Article and Find Full Text PDFBasic Res Cardiol
March 2025
Cardiovascular and Metabolic Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore, Singapore.
Although many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of acute myocardial ischemia/reperfusion injury (IRI), their clinical translation to patient benefit has been largely disappointing. A major factor is the lack of rigor and reproducibility in the preclinical studies. To address this, we have established the IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) small animal multisite acute myocardial infarction (AMI) network, with centralized randomization and blinded core laboratory IS analysis, and have validated the network using ischemic preconditioning (IPC).
View Article and Find Full Text PDFCurr Opin Cardiol
March 2025
Ciccarone Center for the Prevention of Cardiovascular Disease, John Hopkins Hospital, Baltimore, Maryland, USA.
Purpose Of Review: We review the utility of coronary artery calcium (CAC) scoring in personalized risk assessment and initiation of cardiovascular disease risk modifying therapy.
Recent Findings: Many populations - including South Asians, patients with cancer, patients with human immunodeficiency virus (HIV), younger patients, and elderly patients - were not included during the conception of the current risk stratification tools. CAC scoring may allow clinicians to risk-stratify these individuals and help initiate preventive therapy in higher risk populations.
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