Background: Trigeminal neuralgia (TN) is a disease that impairs patients' daily activities. Microvascular decompression (MVD) is known as the best procedure to relieve pain, yet a small portion of patients still experience pain after surgery. This study will analyze the prognostic factor of MVD for TN patients.
Methods: This is a retrospective cohort study of patients with TN who underwent MVD in an Indonesian tertiary hospital from January 2012 to December 2023. It combines medical records and patient interviews followed by statistical analysis to identify prognostic factors influencing the outcome of MVD for TN.
Results: Good response to carbamazepine is a favorable factor for short-term pain-free following MVD ( = 0.01). The type of pain emerged as the sole significant prognostic indicator for short-term ( < 0.001) and long-term ( = 0.04) pain relief following MVD. The duration of pain, the type of blood vessels compressing, and the location of compression demonstrated no statistically significant prognostic value on post-MVD pain-free outcomes.
Conclusion: MVD outcomes are influenced by several factors, including trigeminal pain type (for short and long-term outcomes) and response to carbamazepine (short-term outcomes). Conversely, other factors thought to influence MVD outcomes, such as the duration of pain, the type of blood vessel compressing the nerve, or the site of nerve compression, have not been proven to influence the procedure's outcome.
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http://dx.doi.org/10.25259/SNI_1121_2024 | DOI Listing |
BMJ Open
March 2025
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Introduction: Primary headaches pose a significant burden on children and adolescents, highlighting the need for effective non-pharmacological interventions. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive modality that has demonstrated efficacy in adult populations with primary headaches and has shown safety in adolescents with mental health disorders. However, its effectiveness in managing acute headache episodes and preventing recurrences in paediatric populations remains underexplored.
View Article and Find Full Text PDFJ Ethnopharmacol
March 2025
Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine - Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, China. Electronic address:
Ethnopharmacological Relevance: Pueraria montana var. lobata (PM) has the effects of relieving muscle stiffness and fever, generating body fluids and quenching thirst, resolving rashes, raising yang and stopping diarrhea, unblocking meridians, and detoxifying alcohol. It is commonly used for the management of conditions including stiff neck and back pain, thirst, diabetes, unresolved measles, external fever with headache, dysentery, diarrhea, dizziness and headache, stroke with hemiplegia, chest and heart pain, and alcohol poisoning.
View Article and Find Full Text PDFJ Biol Chem
March 2025
Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, 07103, USA. Electronic address:
Iron-sulfur (FeS) protein biogenesis in eukaryotes is mediated by two different machineries - one in the mitochondria and another in the cytoplasm. Glutaredoxin 5 (Grx5) is a component of the mitochondrial iron-sulfur cluster (ISC) machinery. Here we define the roles of Grx5 in maintaining overall mitochondrial/cellular FeS protein biogenesis, utilizing mitochondria and cytoplasm isolated from Saccharomyces cerevisiae cells.
View Article and Find Full Text PDFJ Pediatr Nurs
March 2025
Mustafa Kemal University, Medical Faculty, Department of Pediatric Cardiology, Hatay, Turkey.
Background: The global COVID-19 pandemic has necessitated the widespread use of N95 masks, yet their impact on children with chronic conditions like type 1 diabetes (T1DM) remains underexplored.
Objective: This study investigates the effects of N95 mask usage on clinical outcomes in children with T1DM.
Methods: This study enrolled 34 children aged 10-18 with T1DM.
J Immunol
February 2025
Orthopedics Department, Central Hospital of Ezhou, Ezhou, China.
Diabetic nephropathy is a severe chronic complication characterized by cytotoxicity, inflammation, and fibrosis, ultimately leading to renal failure. This study systematically investigated the effects of the PARP1 inhibitor PJ-34 on high glucose-induced cytotoxicity, inflammation, and fibrosis in HK-2 cells, as well as its improvement on neuropathic pain response and transforming growth factor β (TGFβ) expression in a type 1 diabetes mellitus diabetic nephropathy mouse model. Through cellular and animal experiments, we observed that PJ-34 significantly enhanced the proliferative capacity of cells damaged by high glucose, reduced apoptosis, and decreased the release of proinflammatory factors TGFα, interleukin-6, and interleukin-1β.
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