The limited availability of information regarding user intent and the surrounding locomotion environment poses obstacles to achieving intuitive prosthetic control. Despite utilizing machine learning algorithms based on external muscle activity and movement sensors to infer user intention, the stringent reliability requirements for leg prostheses control have not been met. This study seeks to enhance the accuracy of locomotion mode detection by incorporating information in the postprocessing phase following Linear Discriminant Analysis classification of locomotion modes. A locomotion dataset comprising data from 15 able-bodied participants, including electromyography, inertial measurement units, and insole pressure sensors during both level walking and stair/ramp ambulation, was employed. To address uncertainties in classification, a threshold-based rejection postprocessing method was implemented, eliminating classifications falling below the threshold. The rejection threshold significantly improved overall locomotion detection accuracy, with transition locomotion showing more pronounced improvement compared to steady-state locomotion. A subanalysis that specifically examined transition locomotion emphasized that biomechanically similar transitions, such as moving from a slight ramp slope to level walking, demonstrated more significant improvement compared to dissimilar transitions like stair to level walking. These findings underscore the significance of leveraging additional information with postprocessing to refine uncertain locomotion classification for better control for prosthetic users.
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http://dx.doi.org/10.1109/EMBC53108.2024.10782478 | DOI Listing |
PLoS One
March 2025
Faculty of Education, Mie University, Mie, Japan.
This study is the first in Japan to prospectively examine the relationship between walking to and from school and physical activity in primary school children. A total of 76 participants completed baseline and follow-up assessments, and their mean age was 9.6 ± 1.
View Article and Find Full Text PDFJ Pediatr Orthop
March 2025
Shriners Children's Portland, Portland, OR.
Background: Toe walking is prevalent among children, affecting 5% to 24% of the pediatric population. Clinicians rely on parental reports of frequency of toe walking to guide clinical decision making and outcomes assessment. However, recall accuracy and differing environments challenge the reliability of parental reports.
View Article and Find Full Text PDFAnal Chem
March 2025
Shandong Key Laboratory of Biophysics, Institute of Biophysics, Institute of Rural Revitalization, School of Pharmacy, Dezhou University, 253023 Dezhou, China.
Peripheral blood circulating tumor DNA (ctDNA) is a crucial liquid biopsy biomarker that correlates overall systemic tumor burden with malignant progression. However, identifying multiple single nucleotide polymorphisms (SNPs) in ctDNA presents significant challenges. In this study, we developed a rolling circle amplification (RCA)-supported multipedal DNA walker integrated with toehold-mediated strand displacement (TSDR) to facilitate the detection of ctDNA SNPs.
View Article and Find Full Text PDFAnn Acad Med Singap
February 2025
Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan.
Introduction: The diagnosis of sarcopenia relies on key indicators such as handgrip strength, walking speed and muscle mass. Developing a composite index that integrates these measures could enhance clinical evaluation in older adults. This study aimed to standardise and combine these metrics to establish a z score for the sarcopenia composite index (ZoSCI) tailored for the ageing population.
View Article and Find Full Text PDFJ Vasc Bras
February 2025
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Background: Early recognition of peripheral tissue perfusion deficits can minimize secondary complications of peripheral arterial disease in individuals with diabetes.
Objectives: To compare parameters of peripheral tissue perfusion in the leg at rest and during and after progressive effort between non-diabetics and individuals with type 2 diabetes and normal ankle brachial index values, as well as to evaluate the factors associated with peripheral tissue perfusion in the leg in individuals with type 2 diabetes during progressive effort.
Methods: This cross-sectional study included 31 individuals with type 2 diabetes and 31 non-diabetics.
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