Brain-computer interface (BCI) has been developed for communication between users and external devices by reflecting users' status and intentions. Motor imagery (MI) is one of the BCI paradigms for controlling external devices by imagining muscle movements. MI-based EEG signals generally tend to contain signals with sparse MI characteristics (sparse MI signals). When conducting domain adaptation (DA) on MI signals with sparse MI signals, it could interrupt the training process. In this paper, we proposed the proxy-based masking module (PMM) for masking sparse MI signals within MI signals. The proposed module was designed to suppress the amplitude of sparse MI signals using the negative similarity-based mask generated between the proxy of rest signals and the feature vectors of MI signals. We attached our proposed module to the conventional DA methods (i.e., the DJDAN, the MAAN, and the DRDA) to verify the effectiveness in the cross-subject environment on dataset 2a of BCI competition IV. When our proposed module was attached to each conventional DA method, the average accuracy was improved by much as 4.67 %, 0.76 %, and 1.72 %, respectively. Hence, we demonstrated that our proposed module could emphasize the information related to MI characteristics. The code of our implementation is accessible on GitHub..
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Ecotoxicol Environ Saf
March 2025
School of Public Health, Beihua University, Jilin 132013, China. Electronic address:
Exposure to di-n-butyl phthalate (DBP) during embryo development or lactation has been linked to reproductive toxicity. The ten-eleven translocation (TET) protein family plays a role in various pathological processes; however, its involvement in reproductive dysfunction in offspring mice exposed to DBP during gestation remains sparsely reported. In this study, SPF C57BL/6 pregnant mice were intragastrically administered DBP at doses of 0.
View Article and Find Full Text PDFAnal Chem
March 2025
Anhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Optoelectronics Engineering, Hefei University of Technology, Hefei 230009, China.
Multidimensional NMR spectroscopy contains a large amount of molecular-level species and structure information, which is of great significance in various disciplines; however, it is unfortunately limited by lengthy acquisition times. Undersampling signals accompanied by spectral reconstruction provide a powerful and efficient way to accelerate its implementation. However, the accurate reconstruction of weak peaks remains a crucial issue to compromise the reconstruction performance.
View Article and Find Full Text PDFNeural Netw
March 2025
University of South Australia, Adelaide, SA, Australia; Systems Research Institute, The Polish Academy of Sciences, Poland.
The dependency on extensive expert knowledge for defining subgoals in hierarchical reinforcement learning (HRL) restricts the training efficiency and adaptability of HRL agents in complex, dynamic environments. Inspired by human-guided causal discovery skills, we proposed a novel method, Human Causal Perception and Inference-driven Hierarchical Reinforcement Learning (HCPI-HRL), designed to infer diverse, effective subgoal structures as intrinsic rewards and incorporate critical objects from dynamic environmental states using stable causal relationships. The HCPI-HRL method is supposed to guide an agent's exploration direction and promote the reuse of learned subgoal structures across different tasks.
View Article and Find Full Text PDFChembiochem
March 2025
University of Gothenburg, Department of Chemistry and Molecular Biology, Medicinaregatan 9c, 40530, Göteborg, SWEDEN.
Cells in all kingdoms of life employ dedicated protein quality control machineries for both their cytosolic and membrane proteome ensuring cellular functionality. These crucial systems consist besides a large variety of molecular chaperones, ensuring a proper fold and consequently function of the client's proteome, of several proteases to clean out damaged, unfunctional and potentially toxic proteins. One of the key features underlying the functional cycle of these quality control systems is the inherent flexibility of their bound clients which for a long time impaired detailed structural characterization, with advanced high-resolution NMR spectroscopy in the last decade playing a key role contributing to the present understanding of their functional properties.
View Article and Find Full Text PDFAdv Sci (Weinh)
March 2025
Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, California, 94305-5344, USA.
Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing the need for accurate and in vivo diagnostic tools that can afford valuable pathophysiological insight into the functioning of neurovascular unit in space and time. Currently, understanding of collateral perfusion and BBB evolution under both physiological and pathological conditions remains sparse, largely owing to limitations in methods for recording diminutive route of cerebral blood flow. Here, it is reported that highly crystalline semiconducting organic nanoprobes (named 4T-BSA) composed of small-molecule dye and bovine serum albumin showed vast potential for live-brain vascular imaging in the second near-infrared window (NIR-II, 1000-1700 nm).
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