Arm cycling has been proven to be an effective exercise for stroke rehabilitation. It strengthens the upper body, improves arm control, and can aid in restoring walking abilities. Promoting the engagement of the paretic arm is crucial, and tailoring the load to accommodate the limitations of the paretic side is a practical approach to encourage the safe use of this arm. We propose that the load modulation can be based on the EMG activity of the weaker side. This work assesses the feasibility of implementing arm cycling with asymmetric loading modulated by EMG activity and proposes a device design. We conducted two user experiments. The results of the first experiment show that asymmetric loading in arm cycling reduces peak activity in the targeted muscles. The second experiment underscores the potential to modulate the magnitude of the load using EMG activity.Clinical relevance- This work explores a novel approach to address motor impairments' unique and evolving challenges.
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http://dx.doi.org/10.1109/EMBC53108.2024.10782844 | DOI Listing |
Front Hum Neurosci
February 2025
Faculty of Electrical Engineering, Automatics and Computer Science, Opole University of Technology, Opole, Poland.
Background: The study includes a correlation analysis of EMG signals of upper limb muscle activity in wheelchair fencers. The aim of the study was to investigate neuromuscular conduction in wheelchair fencers using the EMG signal from their upper limb muscles.
Methods: Wavelet transform analysis was used to examine the biosignals.
BMC Med
March 2025
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Background: We aimed to evaluate the efficacy and safety of cadonilimab (anti-PD-1 and CTLA-4 bispecific antibody) plus TPC chemotherapy (NAB-paclitaxel, cisplatin or lobaplatin, and capecitabine) in patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) who failed to PD-1 inhibitor-containing regimens.
Methods: In this single-arm, open-label, phase 2 study, RM-NPC patients who failed to at least one line of systemic chemotherapy and anti-PD-1 immunotherapy were enrolled and received cadonilimab plus TPC chemotherapy every 3 weeks for up to 6 cycles, followed by cadonilimab plus capecitabine every 3 weeks for a maximum of 2 years. The primary endpoint was the objective response rate (ORR).
Eur Heart J
March 2025
Department of Nephrology, Shanghai Medical Center of Kidney; Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China.
Background And Aims: Remote ischaemic pre-conditioning (RIPC) delivered shortly prior to an angiographic procedure may reduce contrast-associated acute kidney injury (CA-AKI). Whether a longer interval between RIPC and contrast administration also reduces CA-AKI and post-procedural complications after coronary angiography (CAG) or percutaneous coronary intervention (PCI) is unknown.
Methods: This was a multicentre, randomized trial of patients at risk of CA-AKI undergoing elective CAG or PCI comparing delayed RIPC (four cycles of 5 min inflations on one upper arm 24 h before the procedure) with sham RIPC.
IEEE Trans Vis Comput Graph
March 2025
Touch interaction is one of the fundamental interaction paradigms in XR, as users have become very familiar with touch interactions on physical touchscreens. However, users typically need to perform extensive arm movements for engaging with XR user interfaces much larger than mobile device touchscreens. We propose the SummonBrush technique to facilitate easy access to hidden windows while interacting with large XR user interfaces, requiring minimal arm movements.
View Article and Find Full Text PDFmBio
March 2025
Division of Neurological Sciences, NeuroCenter, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Unlabelled: The bacterium () causes listeriosis in humans and ruminants. Acute lesions are predominantly infiltrated by polymorphonuclear neutrophils (PMNs), considered to be the efficient bactericidal arm of innate immunity. However, recent evidence suggests that PMNs cannot achieve antilisterial sterilizing immunity and that may persist within PMNs.
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