Stethoscope screening serves as a primary method for diagnosing pulmonary infections, with medical professionals actively listening for signs of pathologies in breathing sounds like wheezing and crackling, which carry different clinical interpretations. Environmental conditions during auscultation recordings often share similarities with these abnormal lung sounds, and can mask or confound their presence making their detection highly sensitive to surrounding factors. To automate this process, a robust anomaly detection scheme with resilience to ambient backgrounds and high precision is essential. In this study, we propose an unsupervised framework for anomaly detection where statistics of a deep neural network embeddings are tracked using a Bayesian belief model in order to flag variations that are deemed anomalous, hence facilitating detection of adventitious auscultation events. The proposed scheme leverages two key principles: (1) learning of statistics of normal auscultation patterns using variational constraints, and (2) tracking changes in the statistics using Bayesian beliefs that interpret anomalies as deviations from normal statistics. This approach is shown to be very effective in detecting adventitious auscultations under various noise levels hence ensuring its resilience to environmental conditions.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1109/EMBC53108.2024.10782543 | DOI Listing |
J Genet Eng Biotechnol
March 2025
Human Genetics Department, Human Genetics and Genome Research Institute, National Research Centre, Egypt.
Introduction: The fluorescence in situ hybridization (FISH) is a very important technique, as it can diagnose many genetic disorders and cancers. Molecular cytogenetic analysis (FISH) can diagnose numerical chromosome aberrations, sex chromosomes anomalies, and many genetic disorders.
Aim: With the limited number of commercially available probes that do not cover all research needs and the high prices of the commercial probes, our goal is to apply recent technologies to produce FISH probes that can accurately and sensitively diagnose genetic diseases and cancer in Egypt and establishing the inhouse production of different FISH probes.
Neuroimage
March 2025
Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.
An auditory steady-state response (ASSR) is an electrophysiological response to periodic stimuli that reflects the synchronization of endogenous oscillations. The 40-Hz ASSR is reduced in patients with schizophrenia, bipolar disorder, and autism spectrum disorder, making it a candidate biomarker for these psychiatric disorders. Previous studies have revealed that experimental conditions such as stimulus duration and inter-stimulus interval tend to affect ASSR, suggesting that novelty detection may play an important role in determining the magnitude of ASSR.
View Article and Find Full Text PDFAm J Transplant
March 2025
Histocompatibility and Infectious Disease Testing Laboratory, Gift of Hope Organ & Tissue Donor Network, Itasca, IL; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI. Electronic address:
Unexpected transmission of donor-derived diseases, including infections and malignancies, through organ transplantation are occasionally observed and reported. Subclinical, or otherwise undiagnosed, hematological malignancies in potential donors are rare events and typically not identifiable via standard donor evaluation or laboratory testing. Flow cytometric crossmatching (FCXM) is a specialized assay routinely performed in clinical histocompatibility laboratories for the evaluation of immunological compatibility between the recipients and the organ donors through the detection of donor-specific antibodies.
View Article and Find Full Text PDFPediatrics
March 2025
Department of Ophthalmology, Virginia Commonwealth University, Richmond, Virginia.
A 13-month-old girl and a 3-year-old boy were referred to pediatric ophthalmology for leukocoria noticed on a smartphone photograph obtained by the family. Ophthalmologic examination revealed visual acuity appropriate for age and normal dilated fundus exams in both children without signs of retinoblastoma or other ocular abnormalities. Further review of the home photographs revealed optic nerve details in the leukocoric eyes.
View Article and Find Full Text PDFEchocardiography
March 2025
Division of Pediatric Cardiology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Objective: To determine the sensitivity, specificity, and false-positive rate among fetuses suspected prenatally to have coarctation of the aorta (CoA) using size and shape measurements of the fetal heart from the four-chamber view (4CV).
Methods: This was a retrospective study of 108 fetuses identified by pediatric cardiologists to be at risk for CoA. 4CV s from the last antenatal ultrasound performed by the cardiologists were analyzed.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!