Lung diseases contribute significantly to global mortality rates. The conventional diagnostic techniques based on medical imaging used for lung disease diagnosis normally require specialized personnel and complex infrastructure, posing challenges in rural areas. In response to these challenges, Volume Sweep Imaging in the lung (VSI-L) is an ultrasound-based acquisition protocol designed to empower non-specialized healthcare providers by following the movement of the transducer when performing a set of ultrasound scans along the chest. Later, the acquired data is sent to the radiologist for future analysis through a telecommunication system. VSI-L has been tested in clinical trials showing its capacity for tele-ultrasound. Even though it is a standardized protocol, human error remains a concern, which is reflected in not maintaining the correct position and speed of the transducer or producing videos that are difficult for the radiologist to interpret. In response to these challenges, a training system based on an infrared sensor is proposed that allows following the trajectory of the ultrasound transducer, through which the movement coordinates are acquired, which through a Machine Learning program are classified to evaluate whether The ultrasound procedure was performed correctly. This approach showed positive results when classifying the traces made, obtaining an accuracy of approximately 95%.
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http://dx.doi.org/10.1109/EMBC53108.2024.10782311 | DOI Listing |
Sci Adv
March 2025
School of Science and Engineering, Chinese University of Hong Kong, Shenzhen, China.
Intrabronchial delivery of therapeutic agents is critical to the treatment of respiratory diseases. Targeted delivery is demanded because of the off-target accumulation of drugs in normal lung tissues caused by inhalation and the limited motion dexterity of clinical bronchoscopes in tortuous bronchial trees. Herein, we developed microrobotic swarms consisting of magnetic hydrogel microparticles to achieve intrabronchial targeted delivery.
View Article and Find Full Text PDFObjective: Quantitative time of flight in transmission mode ultrasound computed tomography (TFTM USCT) is a promising, cost-effective, and non-invasive modality, particularly suited for functional imaging. However, TFTM USCT encounters resolution challenges due to path information concentration in specific medium regions and uncertainty in transducer positioning. This study proposes a method to enhance resolution and robustness, focusing on low-frequency TFTM USCT for pulmonary imaging.
View Article and Find Full Text PDFAm J Respir Crit Care Med
March 2025
University of Iowa, Radiology and Biomedical Engineering, Iowa City, Iowa, United States;
Rationale: Quantifying functional small airways disease (fSAD) requires additional expiratory computed tomography (CT) scan, limiting clinical applicability. Artificial intelligence (AI) could enable fSAD quantification from chest CT scan at total lung capacity (TLC) alone (fSAD).
Objectives: To evaluate an AI model for estimating fSAD, compare it with dual-volume parametric response mapping fSAD (fSAD), and assess its clinical associations and repeatability in chronic obstructive pulmonary disease (COPD).
Cells
February 2025
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Although every cell biologist knows the importance of selecting the right growth conditions and it is well known that the composition of growth medium may vary depending on a product brand or lot affecting many cellular processes, still those effects are poorly systematized. We addressed this issue by comparing the effect of 12 fetal bovine sera (FBS) and eight growth media from different brands on the morphological and functional parameters of five cell types: lung adenocarcinoma, neuroblastoma, glioblastoma, embryonic kidney, and colorectal cancer cells. Using high-throughput imaging, we compared cell proliferation; performed morphological profiling based on the imaging of 561,519 cells; measured extracellular regulated kinases (ERK1/2) activity, mitochondria potential, and lysosome accumulation; and compared cell sensitivity to drugs, response to EGF stimulation, and ability to differentiate.
View Article and Find Full Text PDFAJR Am J Roentgenol
March 2025
Professor of Radiology, Mayo Clinic College of Medicine and Science, Consultant Radiologist, Division of Cardiothoracic Imaging, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224.
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