In this study, we present the development of a muscle phantom using a hydrogel composed of polyvinyl alcohol (PVA), agar, graphite, and NaCl, cross-linked through freeze/thaw cycling. We compared the properties of the PVA hydrogel with those of a PVA-agar hydrogel filled with graphite and NaCl. To characterize and optimize the mixtures, samples with varying graphite concentrations were prepared, and their electrical properties were measured using bioelectrical impedance spectroscopy (BIS) over a low-frequency range (1 kHz-1 MHz). Two types of studies were carried out: one using 2-electrode standard measuring cells for comparison with literature data, and another using 4-electrode measurement on an anthropomorphic phantom, developed using a 3D-printed mould in the shape of a leg. The mechanical properties of the hydrogel seemed to be very similar to those of living muscle. BIS measurements on the anthropomorphic leg displayed an expected Cole's behaviour, indicating its potential to mimic the electrical properties of living muscle.
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http://dx.doi.org/10.1109/EMBC53108.2024.10782661 | DOI Listing |
Vet Radiol Ultrasound
March 2025
Life Science Facility, Clemson University Genomics and Bioinformatics Facility, Clemson, South Carolina, USA.
Longissimus muscles (LM) in sheep are important for animal scientists who study meat quality and translational researchers who study thoracolumbar spinal disease. Computed tomography (CT) is an established technique for characterizing paraspinal muscles in sheep; however, studies reporting reproducibility of CT measures using open-source software are lacking. The objectives of this prospective pilot study were to develop a standardized protocol for measuring LM area and density in sheep using CT and to determine the reproducibility for measurements.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
July 2024
Studying the soft robot-tissue mechanical interaction in muscle stimulation devices poses a significant challenge due to the complex behavior of the materials involved. To advance this field, this paper models computationally three types of soft elastomeric actuators designed to perform deep cyclic compression stimuli on human soft tissues for muscle rehabilitation by mechanotherapy. The analysis focuses on the interaction between a phantom representing transversely isotropic muscle and homogeneous skin, with a soft robotic device comprised of a hyperelastic actuator and a rigid support.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
July 2024
Tissue-mimicking phantoms (TMPs) have been widely used to simulate human tissues in the pre-clinical study. However, the electrothermal properties of the existing radiofrequency (RF) TMPs cannot satisfy the RF heating for skin treatment and may lead to the inaccuracy thermal distribution. In order to improve the accuracy of thermal distribution caused by RF fields in the phantoms, this study has provided a three-layer TMP (TLTMP) including skin, fat and muscle layers based on polyacrylamide gel (PAG).
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
July 2024
Human phantoms are a viable alternative for in-vitro biomedical device testing, replacing conventional animal tissues and liquid solutions that compromise reproducibility and accuracy. This paper reports a novel human phantom design framework that accurately replicates the electrical properties of human skin, fat, and muscle, using easily accessible and low-cost materials and simple fabrication processes. These phantoms cover an important frequency range of 100 kHz to 50 MHz, which is widely used for wearable and implantable biomedical devices and yet undiscovered.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
July 2024
In this study, we present the development of a muscle phantom using a hydrogel composed of polyvinyl alcohol (PVA), agar, graphite, and NaCl, cross-linked through freeze/thaw cycling. We compared the properties of the PVA hydrogel with those of a PVA-agar hydrogel filled with graphite and NaCl. To characterize and optimize the mixtures, samples with varying graphite concentrations were prepared, and their electrical properties were measured using bioelectrical impedance spectroscopy (BIS) over a low-frequency range (1 kHz-1 MHz).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!