Accurate classification of epileptic seizure types through seizure semiology analysis demands significant clinical expertise. While previous studies have employed various action recognition modules, the scarcity of labeled clinical videos has hindered the deployment of larger models. In this study, we explore unlabeled data to pretrain a transformer-based model with contrastive loss, taking advantage of the information that circumvents the need for additional annotation from medical professionals. We maximize the similarity between embeddings from the same patient and video while minimizing those from different patients and videos. Subsequently, a classification head was finetuned to distinguishing temporal lobe epilepsy (TLE) and extratemporal lobe epilepsy (exTLE), achieving a 5-fold accuracy of 0.93 and an F1 score of 0.88 on the video level (N = 57). Our results outperformed other state-of-the-art seizure classification models, demonstrating the efficacy of our approach. This suggests potential applications in clinical practice, where unlabeled data could serve as a valuable aid in improving seizure classification accuracy and patient care.
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http://dx.doi.org/10.1109/EMBC53108.2024.10781883 | DOI Listing |
Medicine (Baltimore)
March 2025
Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing, Zhejiang, China.
This study aims to systematically evaluate the adverse reactions of flumazenil by analyzing data from the U.S. Food and Drug Administration's Adverse Event Reporting System (FAERS), identifying and quantifying its potential risks across different system organ classifications.
View Article and Find Full Text PDFMinerva Endocrinol (Torino)
March 2025
Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Hypophosphatasia (HPP) is a rare and highly variable genetic disorder of metabolism characterized by markedly reduced serum alkaline phosphatase (ALP) activity as a result of defective production of tissue-non-specific alkaline phosphatase (TNSALP). HPP is known to affect fetuses in utero and also neonates, children, and adults. Severity ranges significantly, from lethal to mild and clinical presentations include rickets or osteomalacia, osteoporosis, respiratory failure and seizures.
View Article and Find Full Text PDFNeurol Ther
March 2025
Senior Department of Paediatrics, The Seventh Medical Centre of PLA General Hospital, Beijing, 100000, China.
Introduction: The treatment of infantile epileptic spasms syndrome (IESS) aims to achieve spasm control. Current first-line interventions include hormone therapy (adrenocorticotropic hormone [ACTH] and corticosteroids) and vigabatrin. Despite treatment, the response rate remains at around 40%, with some infants experiencing relapse after achieving initial spasm control.
View Article and Find Full Text PDFBiochemistry (Mosc)
January 2025
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.
In neurophysiology, the transmitter phenotype is considered as an indicator of neuronal identity. It has become known at the end of last century that a nerve cell can produce and use several different molecules to communicate with other neurons. These could be "classical" transmitters: glutamate or gamma-aminobutyric acid (or acetylcholine, serotonin, norepinephrine), as well as secondary messengers, mainly neuropeptides released from the same neurons.
View Article and Find Full Text PDFEpilepsy Behav
March 2025
Department of Nuclear Medicine, PET/CT-MRI Center, Center of Cyclotron and PET Radiopharmaceuticals, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510632, China. Electronic address:
Purpose: This study retrospectively analyzed preoperative arterial spin labeling (ASL) perfusion MRI data of patients with the temporal-insula type of temporal plus epilepsy (TI-TPE). We aimed to investigate the differences in presurgical cerebral blood flow (CBF) changes in TI-TPE patients with different surgical outcomes.
Method: A total of 48 TI-TPE patients confirmed by SEEG were meticulously reviewed for this study.
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