Low intensity focused ultrasound stimulation targeted on M1 ameliorates neuroinflammation in hemi-parkinsonian rats.
Annu Int Conf IEEE Eng Med Biol Soc
Published: July 2024
Objective: Low intensity focused stimulation (LIFUS) has been proved to improve motor function in Parkinson's disease (PD) animal modules. The aim of this study is to investigate whether LIFUS target on the primary motor cortex (M1) can improve motor deficit in the PD rats.
Methods: The PD rat model was induced by injection of 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle (MFB). Two weeks after the injection, LIFUS was used on PD rats for two weeks. Behavioral tests were performed including open field test and rotarod test to examine the motor ability of the rats. The activity of microglia and astrocyte were tested to evaluate the inflammation level in the brain. The tyrosine hydroxylase (TH) staining was done to detect the recovery of dopaminergic (DA) neurons in the substantia nigra (SN) and DA fibers in the striatum (STR).
Results: LIFUS treatment decreased the resting time in OFT(p<0.05) and increased the latency to falls in the rotarod test(p<0.05) compared with the untreated PD rats. Moreover, LIFUS reduced the inflammation response reflected in microglia and astrocyte activation. Additionally, TH-immunoreactive fibers increased in the STR after LIFUS.
Conclusion: These findings demonstrated that LIPUS targeted on M1 can inhibit neuroinflammation and improve movement disorders of PD rats.
Significance: This study provides a new therapeutic strategy for further clinical application in PD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/EMBC53108.2024.10781691 | DOI Listing |
Similar Publications
Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation-Reply.
JAMA
March 2025
Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Beijing, China.
Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation.
JAMA
March 2025
College of Medicine, University of Florida, Jacksonville.
Pretreatment Liquid Biopsy and Clinicopathologic Features in HPV-Associated Oropharyngeal Squamous Cell Carcinoma.
JAMA Otolaryngol Head Neck Surg
March 2025
Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
Importance: Despite the favorable prognosis for HPV-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC), efforts to de-escalate treatment intensity, while maintaining low recurrence and mortality rates, have proven challenging. Identifying appropriate prognostic factors remains elusive; however, the association of pretreatment circulating tumor tissue viral-modified HPV (TTMV-HPV) DNA level with known characteristics of disease burden-clinical staging, characteristics of pretreatment imaging, and aggressive histopathologic features of surgical specimen-may offer insights that could shift treatment paradigms for HPV+ OPSCC.
Objective: To investigate the association of pretreatment TTMV-HPV DNA levels with clinical, radiologic, histopathologic, and outcome metrics in patients with HPV+ OPSCC.
The objective of this study was to validate the usefulness of the W-index (WI) for screening patients at risk of osteoporosis by correlating the WI results with those obtained from peripheral dual-energy X-ray absorptiometry (pDXA). The W-index is based on oblique line contrast on panoramic radiographs, in which the pixel intensity of the oblique line is compared with the pixel intensity of adjacent structures at the mandibular ramus. A total of 333 patients with panoramic radiographs and pDXA results were evaluated according to T-score results and WI measurements.
View Article and Find Full Text PDFTechnology-enabled upper limb (UL) rehabilitation improves therapy intensity and impairment outcomes, however clinical usage remains low and evidence for functional outcomes is limited. While benefits of single-mode technologies have been demonstrated, a combination of technology modes or "hybrid" approach is an emerging option with shoulder to fingertip capability. Investigation of this approach within a hospital setting is warranted to inform occupational therapy practice with neurological patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.