Effective identification of damage characteristics and failure modes for buried pipelines subjected to fault movements is crucial for early design and disaster assessment. In the preceding companion paper, the structural responses of large-diameter prestressed concrete cylinder pipeline (PCCP) subjected to fault displacement were initially investigated under the condition where faulting crosses pipe barrel vertically, and the deterioration process and failure modes were summarized. However, the structural responses of jointed pipelines are closely tied to faulting parameters. In this paper, a study on the location and angle of the fault plane is conducted, and the damage response and failure modes of large-diameter PCCPs are analyzed in detail and compared. The results show that strike-slip fault movement causes pipeline movement through pipe-soil interaction, and the fault displacement is accommodated by several pipe segments for the large diameter-to-length ratio PCCPs. When the fault plane crosses the pipe segment at an acute angle, the primary failure modes include material damage to the pipe joints and barrel, as well as the risk of joint leakage. Material damage occurs at the joint when the fault plane passes through the PCCP joint. Given the mechanical properties and seismic resilience of PCCPs, it is advisable to avoid faulting at acute angles crossing pipeline joints. This work focuses on the structural behavior of segmented composited PCCPs crossing a fault, aiming to predict pipeline damage and failure. The findings contribute to a comprehensive understanding of the failure modes, damage characteristics, and disaster evaluation of PCCPs under strike-slip fault conditions.
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http://dx.doi.org/10.1038/s41598-025-91442-w | DOI Listing |
BMC Oral Health
March 2025
Division of Prosthodontics, Faculty of Dentistry, Thammasat University, Pathumthani, 12120, Thailand.
Background: Increased bond strength between aged CAD/CAM (Computer-Aided Design and Computer-Aided Manufacturing) provisional restorative materials is essential for reparability. This study investigated the impact of three different solvents and airborne-particle abrasion on the shear bond strength (SBS) of aged CAD/CAM provisional restorative materials, which are milled PMMA and 3D-printed resin with flowable resin composite.
Methods: 3D-printed resin and milled PMMA (N = 160 per type) were fabricated into cylindrical shapes (5 mm in diameter, 5 mm in height), aged by 5,000 thermocycling cycles, and randomize divided at random into five groups (N = 32) based on surface modification protocols: control; non-surface modification, MEK; application with methyl ethyl ketone, THF; application with tetrahydrofuran, Alc; application with isopropyl alcohol, and APA; airborne-particle abrasion with 50-µm alumina oxide particle.
J Appl Clin Med Phys
March 2025
Division of Radiation Biophysics, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Current radiotherapy machines intended to perform streamlined online adaptive therapy are designed to be standalone, which makes it challenging to integrate them with the rest of the clinic. This work describes the installation of a standalone CT-guided online adaptive system, the Varian Ethos, in a busy clinic utilizing products from multiple vendors, including RayStation as the treatment planning system (TPS) and MOSAIQ as the oncology information system (OIS). The aim was to develop solutions that minimized workload increases for staff using redundant systems and to implement this new technology safely, with no increase in safety reports resulting from its integration into the clinic.
View Article and Find Full Text PDFChem Res Toxicol
March 2025
Bayer AG, Pharmaceuticals, 13353 Berlin, Germany.
Drug-induced liver injury (DILI) is a major cause of drug development failures and postmarket drug withdrawals, posing significant challenges to public health and pharmaceutical research. The biological mechanisms leading to DILI are highly complex and the adverse reaction is often difficult to foresee. Hence, mechanistic insights into DILI, as well as machine learning models to predict molecular events that trigger adverse outcomes, pharmacokinetics and pharmacodynamics in the liver, are essential tools for understanding and preventing DILI.
View Article and Find Full Text PDFPLoS One
March 2025
Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, China.
Objective: Point-of-care testing (POCT) blood glucose meters provide rapid and convenient monitoring for clinical care and chronic disease management. However, their accuracy is often compromised by risks associated with personnel, equipment, and procedural inconsistencies. This study systematically assesses these risks using the Failure Mode and Effects Analysis (FMEA) method and proposes control measures aligned with ISO 15189:2022 standards.
View Article and Find Full Text PDFSmall molecule kinase inhibitors are critical in the modern treatment of cancers, evidenced by the existence of over 80 FDA-approved small-molecule kinase inhibitors. Unfortunately, intrinsic or acquired resistance, often causing therapy discontinuation, is frequently caused by mutations in the kinase therapeutic target. The advent of clinical tumor sequencing has opened additional opportunities for precision oncology to improve patient outcomes by pairing optimal therapies with tumor mutation profiles.
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