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Large language models for surgical informed consent: an ethical perspective on simulated empathy.
J Med Ethics
March 2025
Institute for Ethics, History and Philosophy of Medicine, Hannover Medical School, Hannover, Germany.
Informed consent in surgical settings requires not only the accurate communication of medical information but also the establishment of trust through empathic engagement. The use of large language models (LLMs) offers a novel opportunity to enhance the informed consent process by combining advanced information retrieval capabilities with simulated emotional responsiveness. However, the ethical implications of simulated empathy raise concerns about patient autonomy, trust and transparency.
View Article and Find Full Text PDFPerspectives on adhesion and irreversible fouling to delineate mitigation effects of autoinducer-2 mediated quorum quenching on biofouling.
Bioresour Technol
March 2025
Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China. Electronic address:
This study systematically investigated the effect of interfering with autoinducer-2 (AI-2) signaling system on controlling initial fouling attachment and irreversible components. Exposure of bacteria to the inhibitor significantly reduced the expression of the luxS gene, which resulted in a 37.3% reduction of AI-2 signaling molecule synthesis.
View Article and Find Full Text PDFExosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy.
Mech Ageing Dev
March 2025
Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, India. Electronic address:
Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated to developing effective therapeutics to target cancer cells. One promising strategy involves inducing cellular senescence, a complex state in which cells exit the cell cycle.
View Article and Find Full Text PDFMitochondrial DNA in atherosclerosis: Mechanisms, biomarker potential, and therapeutic perspectives.
Int Immunopharmacol
March 2025
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Electronic address:
Atherosclerosis is a chronic inflammatory disease in which mitochondrial DNA (mtDNA) has emerged as a key contributor to its pathogenesis. We synthesized evidence from experimental and clinical studies showing that mtDNA damage, release, and mutation profoundly affect endothelial cells, macrophages, and vascular smooth muscle cells, thereby driving plaque initiation and progression. By activating immune signaling pathways-including cGAS-STING, NLRP3 inflammasome, and TLR9-mtDNA amplifies inflammation and oxidative stress, exacerbating atherosclerotic lesion development.
View Article and Find Full Text PDFA high-resolution N-glycoproteome landscape of aging mouse ovary.
Redox Biol
March 2025
Laboratory for Disease Glycoproteomics, College of Life Sciences, Northwest University, Xi'an, 710069, PR China. Electronic address:
Ovarian aging typically precedes the decline of other organ systems, yet its molecular mechanisms remain poorly understood. Glycosylation as one of the most important protein modifications has been especially unexplored in this context. Here, we present the first high-resolution glycoproteomic landscape of aging mouse ovaries, uncovering site-specific N-glycan signatures across subcellular components such as high proportions of complex glycans, core fucosylation, and LacdiNAc branches at the zone pellucida.
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