Objective: To estimate the optic nerve head morphology from its haemoglobin (Hb) distribution.
Methods And Analysis: The optic disc of 189 normal eyes and 292 with confirmed and suspected glaucoma were analysed with Spectralis-OCT and the Laguna ONhE application using the Topcon NW400 fundus camera. Topographic Hb values were correlated with OCT tissue thicknesses from Bruch's membrane. The neuroretinal rim volume (RV), the cup volume (CV) and their relation to the globin distribution function (GDF) index of Laguna ONhE were analysed. The results were applied to 1 163 241 optic nerve images obtained in a glaucoma screening setting. Differences in segmentation and the presence of vessels without local nutritional function are the main limitations of the comparison.
Results: The correlation between local Hb density and the tissue thicknesses from Bruch's membrane was R=0.953 (p<0.0001). RV could be estimated from pixel-to-pixel Hb values with an R=0.650 (p<0.0001) and from six Laguna ONhE indices with an R=0.786 (p<0.0001). CV could be estimated with an R=0.762 (p<0.0001). RV had a mean value of 0.396 mm (SD=0.187) for positive GDF values and usually below 0.210 mm for negative GDF. The distribution of RV values in the screening series was congruent with that found in the prospective series, with a higher value in large nerves.
Conclusions: The volume and shape of the optic nerve tissue are closely related to its perfusion and can be deduced from it. The relationship between the RV and GDF is curvilinear and suggests that perfusion measurement may bring the diagnosis forward in earlier stages.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881183 | PMC |
| http://dx.doi.org/10.1136/bmjophth-2024-002024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictive factors for visual prognosis in neurosyphilis presenting with optic atrophy: a Chinese case series study.
Front Neurol
February 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Background: We aimed to explore the clinical features and predictive factors for visual prognosis of neurosyphilis-associated optic atrophy (NSAOA).
Methods: This retrospective observational study included 17 patients (33 eyes) with NSAOA who received standard anti-ocular syphilis treatment. LogMAR (logarithm of the minimum angle of resolution) best-corrected visual acuity (BCVA), visual field, and optical coherence tomography, were recorded at baseline, short-term (within one month after treatment), and long-term (> 6 months) follow-up.
A Race Against Time: Rapidly Progressive Methicillin Resistant Pansinusitis with Vision Loss in an Immunocompetent Child.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Otorhinolaryngology, AIIMS Nagpur, Nagpur, India.
Acute sinusitis is a relatively common condition in pediatric patients. In most cases, it resolves completely with prompt medical management, but its rapid progression to severe orbital complications leading to restriction of extra-ocular movements and negative perception of light in the affected eye is rare and pose diagnostic and management challenges. The aggressive nature of acute rhinosinusitis requires urgent surgical intervention coupled with prompt medical management to prevent life threatening complications and outcomes.
View Article and Find Full Text PDFVascular supply of the eye: clinical anatomy.
Med Hypothesis Discov Innov Ophthalmol
February 2025
Dokuz Eylul University, Department of Ophthalmology, Izmir, Turkiye.
Background: Eye function is vitally dependent on an adequate blood supply, primarily provided by the ophthalmic artery, an internal carotid artery branch. This review provides an overview of the vascular supply of the eye.
Methods: A targeted search of PubMed / MEDLINE was performed using the terms "central retinal vein," "central retinal artery," "internal carotid artery," "ophthalmic artery," "ophthalmic vein," "posterior ciliary arteries," "retinal capillaries," "vascular supply of the eye," "ocular vascular supply," "external carotid artery," and "vortex vein".
Compact Monocular Video-Ophthalmoscope to Measure Retinal Reflectance Changes to Flicker Light Stimuli.
J Biophotonics
March 2025
Department of Ophthalmology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
This paper describes a compact video-ophthalmoscope (VO) designed for capturing retinal video sequences of the optic nerve head (ONH) under flicker light stimulation. The device uses an OLED display and a fiber optic-coupled LED light source, enabling high-frame-rate video at low illumination intensity (12 μW/cm). Retinal responses were recorded in 10 healthy subjects during flicker light exposure with a pupil irradiance of 2 μW/cm.
View Article and Find Full Text PDFVision Loss in Neurocysticercosis: A Systematic Review of Case Reports and Series.
J Clin Neurol
March 2025
Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
Background And Purpose: Neurocysticercosis is a parasitic infection caused by larvae that leads to various neurological symptoms, including vision loss. This systematic review analyzed cases of vision loss associated with neurocysticercosis to assess its etiology and vision outcomes.
Methods: Following PRISMA guidelines, the review included reports on human subjects with vision loss due to neurocysticercosis and is registered with PROSPERO (CRD42024556278).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!