Sexually transmitted infections remain common globally and most frequently are asymptomatic. The 2025 European guideline provides up-to-date guidance regarding indications for testing and treatment of infections. It includes advice on urogenital and extragenital testing including the use of self-collected specimens; recommendation to use only validated NAATs for diagnosis; and recommendation to treat all infections with doxycycline as first line in preference to single-dose azithromycin regimens. The absence of evidence and limited value of broad screening in asymptomatic populations for infections is also discussed.
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