In this NeuroView, we discuss challenges and best practices when dealing with disease-detection AI models that are trained on heterogeneous clinical data, focusing on the interrelated problems of model bias, causality, and rare diseases.
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| http://dx.doi.org/10.1016/j.neuron.2025.01.028 | DOI Listing |
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Retinoid X receptor agonist 9CDHRA mitigates retinal ganglion cell apoptosis and neuroinflammation in a mouse model of glaucoma.
FASEB J
March 2025
Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs) and optic nerve damage, often associated with elevated intraocular pressure (IOP). Retinoid X receptors (RXRs) are ligand-activated transcription factors crucial for neuroprotection, as they regulate gene expression to promote neuronal survival via several biochemical networks and reduce neuroinflammation. This study investigated the therapeutic potential of 9-cis-13,14-dihydroretinoic acid (9CDHRA), an endogenous retinoid RXR agonist, in mitigating RGC degeneration in a high-IOP-induced experimental model of glaucoma.
View Article and Find Full Text PDFLayered-Hierarchical Dual-Lattice Strain Suppresses NiSe Surface Reconstruction for Stable OER in Alkaline Fresh/Seawater Splitting.
Small
March 2025
College of Materials Science and Engineering, Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy, Hunan University, Changsha, 410082, P. R. China.
Transition metal selenides (TMSe) are promising oxygen evolution reaction (OER) electrocatalysts but act as precursors rather than the actual active phase, transforming into amorphous oxyhydroxides during OER. This transformation, along with the formation of selenium oxyanions and unstable heterointerfaces, complicates the structure-activity relationship and reduces stability. This work introduces novel "layered-hierarchical dual lattice strain engineering" to inhibit the surface reconstruction of NiSe by modulating both the nickel foam (NF) substrate with MoN nanosheets (NM) and the NiSe nanorods-nanosheets catalytic layer (NiSe-NiSe-NiO, NSN) with ultrafast interfacial bimetallic amorphous NiFeOOH coating, achieving the optimized NM/NSN/NiFeOOH configuration.
View Article and Find Full Text PDFChallenges and Opportunities for Rechargeable Aqueous Sn Metal Batteries.
Adv Mater
March 2025
Pritzker School of Molecular Engineering, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, 60637, USA.
Rechargeable aqueous batteries based on metallic anodes hold tremendous potential of high energy density enabled by the combination of relatively low working potential and large capacity while retaining the intrinsic safety nature and economical value of aqueous systems; However, the realization of these promised advantages relies on the identification of an ideal metal anode chemistry with all these merits. In this review, the emerging Sn metal anode chemistry is examined as such an anode candidate in both acidic and alkaline media, where the inertness of Sn toward hydrogen evolution, flat low voltage profile, and low polarization make it a unique metal anode for aqueous batteries. From a panoramic viewpoint, the key challenges and detrimental issues of Sn metal batteries are discussed, including dead Sn formation, self-discharge, and electrolyte degradation, as well as strategies for mitigating these issues by constructing robust Sn anodes.
View Article and Find Full Text PDFAnimal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies.
Front Immunol
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Department of Public Laboratory, The Third People's Hospital of Kunming City/Infectious Disease Clinical Medical Center of Yunnan Province, Kunming, Yunnan, China.
Animal models are indispensable for unraveling the mechanisms underlying post-acute sequelae of COVID-19 (PASC). This review evaluates recent research on PASC-related perturbations in animal models, drawing comparisons with clinical findings. Despite the limited number of studies on post-COVID conditions, particularly those extending beyond three months, these studies provide valuable insights.
View Article and Find Full Text PDFEvaluating human exposure to antibiotic resistance genes.
Biosaf Health
April 2024
College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Antibiotic resistance is an escalating global concern, leading to millions of annual fatalities. Antibiotic resistance genes (ARGs) present in bacteria equip them to withstand the effects of antibiotics. Intra- and interspecific ARGs transmission through horizontal gene transfer further exacerbates resistance dissemination.
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