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Long Non-Coding RNA Osr2 Promotes Fusarium solani Keratitis Inflammation via the miR-30a-3p/ Xcr1 Axis.
Invest Ophthalmol Vis Sci
March 2025
Department of Ophthalmology, Fujian Medical University Union Hospital, Fu Zhou, China.
Purpose: Fungal keratitis (FK) is a challenging and sight-threatening corneal disease caused by fungal infections. Although long noncoding RNAs (lncRNAs) have been explored in various infectious diseases, their specific roles in FK remain largely unexplored.
Methods: A mouse model of FK was created by infecting corneal stromal cells with Fusarium solani.
Hyalohyphomycosis caused by Antifungal-resistance Scopulariopsis brevicaulis in a patient with CARD9 deficiency.
Br J Dermatol
February 2025
Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, P.R.China.
Posaconazole effectiveness in rare invasive fungal infections: A systematic literature review.
Int J Antimicrob Agents
February 2025
OPEN Health, Bethesda, MD, USA.
Introduction: Mucormycosis, hyalohyphomycosis, chromoblastomycosis, and fungal mycetoma are rare invasive fungal infections (IFIs) that cause significant morbidity and mortality in immunocompromised patients. Few effective treatment options are available for these IFIs.
Methods: We performed a systematic literature review of MEDLINE and Embase to identify studies published from 2005 (year of posaconazole approval) to October 22, 2022, reporting the efficacy/effectiveness of posaconazole monotherapy or combination therapy for treating mucormycosis, hyalohyphomycosis, chromoblastomycosis, and mycetoma.
Background: Fusarium species is a facultative pathogen capable of causing invasive infections in patients with hematological malignancies after allogeneic hematopoietic stem cell transplantation (HSCT).
Methods: We retrospectively analyzed a case of T-lymphoblastic lymphoma combined with disseminated fusariosis after HSCT in our hospital. Case reports of Fusarium fungemia in patients with hematological disorders over the past 20 years in Asia were reviewed.
Molecular Tracking of Emerging Fusarium Species in Keratitis: F. veterinarium, F. contaminatum, and F. curvatum.
Mycopathologia
February 2025
Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Discipline of Cellular Biology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Fungal keratitis, which is caused primarily by Neocosmospora and Fusarium species, is a significant global health issue that affects more than a million people annually in tropical and subtropical regions. Neocosmospora solani (formerly Fusarium solani) is a leading cause of corneal infections, along with members of the Fusarium oxysporum species complex (FOSC). This study provides new insights by reporting a series of ocular fusariosis cases caused by FOSC members and presenting molecular evidence linking specific haplotypes within FOSC to human infections.
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