Recently, flexible electronics have significantly transformed information and communications technology (ICT). In particular, wearable devices, via integration with attachable biosensors, have driven the development of new types of biosensors and diagnostic devices for point-of-care testing (POCT). Moreover, wearable electrochemical biosensors can be applied to diagnose diseases in real time based on the synergistic effect generated from the incorporation of the electrochemical technique. Besides, to improve the sensitivity of electrochemical biosensors while retaining their wearability, novel nanomaterials and nanotechnologies have been introduced. In this review, recent studies on nanotechnology-based wearable electrochemical biosensors for accurate disease diagnosis are discussed. First, widely used techniques for developing flexible electrodes, including nanolithography- and nano/microneedle-based patches, are presented. Next, the latest studies on developing wearable electrochemical biosensors for the diagnosis of diseases such as diabetes and dermatitis are discussed by categorizing the biosensors into nanolithography- and nano/microneedle-based categories. Finally, this review explores the latest research trends on the application of nanotechnology-enabled nanopatterning and nano/microneedle technologies to electrochemical wearable biosensors. This review suggests novel approaches and methods for developing wearable electrochemical biosensors for real-time disease diagnosis under POCT applications.
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