Autophagy-related gene 6 (ATG6) plays a crucial role in plant immunity. Nonexpressor of pathogenesis-related genes 1 (NPR1) acts as a signaling hub of plant immunity. However, the relationship between ATG6 and NPR1 is unclear. Here, we find that ATG6 directly interacts with NPR1. overexpression significantly increased nuclear accumulation of NPR1. Furthermore, we demonstrate that increases NPR1 protein levels and improves its stability. Interestingly, ATG6 promotes the formation of SINCs (SA-induced NPR1 condensates)-like condensates. Additionally, ATG6 and NPR1 synergistically promote the expression of genes. Further results showed that silencing in exacerbates DC3000/ infection, while double overexpression of and synergistically inhibits DC3000/ infection. In summary, our findings unveil an interplay of NPR1 with ATG6 and elucidate important molecular mechanisms for enhancing plant immunity.
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| http://dx.doi.org/10.7554/eLife.97206 | DOI Listing |
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