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The Mental Well-Being of Graduate Students in Canada: A Scoping Review.
Am J Health Promot
March 2025
Social Justice in Mental Health Research Lab, School of Occupational Therapy, Western University, London, ON, Canada.
To review the literature exploring the mental health of graduate students in Canada. Data Source: Articles identified in EMBASE, CINAHL, PsycInfo, Medline, Sociological Abstracts, Nursing and Allied Health, and ERIC.Study Inclusion and Exclusion Criteria:Two independent reviewers screened articles that: (1) focused on graduate students' mental wellbeing; (2) used empirical study designs (3) were published in English; (4) were conducted in Canada.
View Article and Find Full Text PDFBispecific antibody therapy for lymphoma.
Best Pract Res Clin Haematol
December 2024
330 Brookline Ave, Boston, MA, 02215, USA. Electronic address:
The rapid development of novel therapeutics in B-cell Non-Hodgkin's lymphoma (B-NHL) over the past decade has presented a critical inflection point for the field. Bispecific antibodies are one such therapeutic class emerging as an effective, off-the-shelf option for B-NHL. In this review, we focus primarily on Diffuse Large B-cell Lymphoma (DLBCL), highlighting the evolution, comparison, tolerability, ongoing challenges, and future potential of bispecific antibodies that are currently approved or in clinical trials for B-NHL.
View Article and Find Full Text PDFResearch quality and dissemination of paediatric randomised controlled trials with and without patient and family engagement: systematic review.
BMJ Open
March 2025
Division of Paediatric Medicine and Paediatric Outcomes Research Team (PORT), The Hospital for Sick Children, Toronto, Ontario, Canada.
Objectives: Authentic patient and family engagement in child health research is defined as researchers working in partnership with patients and families on all aspects of the research process, including refining the research question, tailoring the intervention, devising study procedures and disseminating study findings. While there is good evidence of a positive impact of patient engagement on the research process, on research teams and on patient partners, there are few empirical data on the impact of patient and family engagement on research quality and dissemination. We conducted a systematic review to compare research quality and dissemination metrics for paediatric randomised controlled trials (RCTs) that engaged patients and families in the research process with trials that did not.
View Article and Find Full Text PDFSpecial Issue on CDS Failures: A Case Study: Optimizing CDS for Pediatric Oncology Trials by Transitioning from Interruptive to Passive Alerts.
Appl Clin Inform
March 2025
Department of Pediatrics, Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
Background: Many children with cancer are treated as part of interventional clinical trials. Ensuring that the correct chemotherapy treatment plan is used is paramount.
Objectives: The objectives of this report were to: (1) highlight the initial design of a clinical decision support (CDS) tool that was intended to help ensure the correct matching of research studies to research chemotherapy medications, (2) discuss the issues identified with the CDS tool, and (3) review the redesign of the tool that was done to overcome the issues identified.
No Difference in Two-Year Outcomes of Arthroscopic Rotator Cuff Repair in Patients with Osteoporosis.
J Shoulder Elbow Surg
March 2025
Steadman Hawkins Clinic of the Carolinas, Prisma Health, Greenville, SC, USA. Electronic address:
Background: Many prognostic factors associated with healing after arthroscopic rotator cuff repair have been evaluated. It has been shown from previous literature that osteoporosis is an independent risk factor for poor healing and increased need for revision surgery. To our knowledge, there has not been a study reporting patient reported outcomes (PROs) for arthroscopic rotator cuff repair in patients with osteoporosis.
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