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Bispecific antibody therapy for lymphoma.
Best Pract Res Clin Haematol
December 2024
330 Brookline Ave, Boston, MA, 02215, USA. Electronic address:
The rapid development of novel therapeutics in B-cell Non-Hodgkin's lymphoma (B-NHL) over the past decade has presented a critical inflection point for the field. Bispecific antibodies are one such therapeutic class emerging as an effective, off-the-shelf option for B-NHL. In this review, we focus primarily on Diffuse Large B-cell Lymphoma (DLBCL), highlighting the evolution, comparison, tolerability, ongoing challenges, and future potential of bispecific antibodies that are currently approved or in clinical trials for B-NHL.
View Article and Find Full Text PDFNanoFlora: Unveiling the therapeutic potential of Ipomoea aquatica nanoparticles.
J Genet Eng Biotechnol
March 2025
Karpagam College of Pharmacy, Coimbatore 641 032 Tamil Nadu, India; The Tamil Nadu Dr. M.G.R. Medical University, Chennai 600032 Tamil Nadu, India. Electronic address:
Introduction: Improving the pharmacokinetics of drugs is achieved through nano formulations and the role of natural product in the synthesis of nanomaterials is gaining prominence due to its eco-friendly nature, cost-effectiveness, and demonstrated efficacy. Metal nanoparticles (NPs) derived from Ipomoea aquatica Forsskal have been synthesized and evaluated for their antioxidant and antidiabetic properties towards enhancing the anticancer activity of the plant extracts.
Methodology: Hydroalcoholic extract was obtained from the entire Ipomoea aquatica plant and utilized as a key ingredient in the green synthesis of metal NPs.
Establishing Cross-Specialty Expert Consensus on the Optimal Management of Hyperkalemia in Patients With Heart Failure and Chronic Kidney Disease.
Circ J
March 2025
Kawasaki Geriatric Medical Center, Kawasaki Medical School.
Background: Patients with both heart failure (HF) and chronic kidney disease (CKD) are often treated with renin-angiotensin-aldosterone system inhibitors (RAASi), but these drugs can cause hyperkalemia, which may lead to their reduction or discontinuation, resulting in the loss of their beneficial effects. Approaches to managing RAASi-induced hyperkalemia are discordant, so in this study we aimed to establish a cross-specialty consensus on the optimal approach to managing hyperkalemia in patients with HF and CKD.
Methods And Results: The study used a modified Delphi methodology.
In vitro study of a siRNA delivery liposome constructed with an ionizable cationic lipid.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Pharmaceutical Engineering, Chemistry and Chemical Engineering, Central South University, Changsha 410083.
Objectives: Small interfering RNA (siRNA) can silence disease-related genes through sequence-specific RNA interference (RNAi). Cationic lipid-based liposomes effectively deliver nucleic acids into the cytoplasm but often exhibit significant toxicity. This study aims to synthesize a novel ionizable lipid, Nε-laruoyl-lysine amide (LKA), from natural amino acids, constructed LKA-based liposomes, and perform physicochemical characterization and cell-based experiments to systematically evaluate the potential of these ionizable lipid-based liposomes for nucleic acid delivery.
View Article and Find Full Text PDFDynamic changes in the distribution equilibrium of drugs in microemulsions associated with drug absorption facilitate the absorption improvement for drugs with low water-solubility by self-microemulsifying drug delivery system (SMEDDS).
Int J Pharm
March 2025
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. Electronic address:
Mechanisms for absorption improvement of drugs with low water-solubility by self-microemulsifying drug delivery system (SMEDDS) are still controversial except for solubility improvement. We attempted to clarify the mechanisms by utilizing model drugs classified as biopharmaceutics classification system class II. In the in-vitro transport study for microemulsions (MEs) formed from SMEDDS, the permeation clearance (CL) calculated based on free drug concentrations in MEs, was significantly larger than the CL for aqueous solution.
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