It has long been appreciated that farm exposure early in life protects individuals from allergic asthma. Understanding what component(s) of this exposure is responsible for this protection is crucial to understanding allergic asthma pathogenesis and developing strategies to prevent or treat allergic asthma. In this review, we introduce the concept of Farm-Friends, or specific microbes associated with both a farm environment and protection from allergic asthma. We review the mechanism(s) by which these Farm-Friends suppress allergic inflammation, with a focus on the molecule(s) produced by these Farm-Friends. Finally, we discuss the relevance of Farm-Friend administration (oral vs. inhaled) for preventing the development and severity of allergic asthma throughout childhood and adulthood. By developing a fuller understanding of which Farm-Friends modulate host immunity, a greater wealth of prophylactic and therapeutic options becomes available to counter the current allergy epidemic.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877632 | PMC |
| http://dx.doi.org/10.1111/imr.70012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A review in analytical progress for house dust mite allergens.
Rev Environ Health
March 2025
Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, Hangzhou, China.
House dust mite (HDM) allergens are one of the most important causes of allergenic diseases in the indoor environment. The World Health Organization (WHO) has defined risk thresholds for Group I HDM allergens as a concentration of 2 and 10 μg/mL in dust for producing asthma risk and polar asthma attacks, respectively. Continuing exposure to high concentrations of HDM allergens greatly increases the risk of developing allergic diseases.
View Article and Find Full Text PDFClimate Change and Allergens: Current and Future Impacts.
J Allergy Clin Immunol Pract
March 2025
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. Electronic address:
Climate change will continue to impact allergic diseases in direct and indirect ways. Rising global temperatures are contributing to increased duration of pollen seasons, altered aeroallergen production and potency of allergens, and changes in the geographic distribution of allergenic plants that drive increased human exposure to aeroallergens and increased allergic disease morbidity. Climate change is inextricably linked with air pollution, the latter of which was shown to act as an adjuvant for allergic inflammatory processes promoting allergic sensitization.
View Article and Find Full Text PDFProtease-activated receptor 2 and IL-13Rα1 activation is linked to eosinophilic chronic rhinosinusitis.
Ann Allergy Asthma Immunol
March 2025
Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Department of Otolaryngology, Head and Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan; Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei, Taiwan; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan; Department of Early Childhood Care and Education, Cheng Shiu University. Electronic address:
Background: Protease-activated receptor 2 (PAR-2) and IL-13 receptor α1 (IL-13Rα1) play major roles in type 2 inflammation. However, most of the literature was limited to allergic asthma.
Objective: This study examined how these receptors contribute to upper respiratory tract inflammation and explored potential therapeutic targets in patients with eosinophilic chronic rhinosinusitis (eCRS).
HGF-DPSCs ameliorate asthma by regulating CCR1 Th2 cells responses in mice pulmonary mucosa.
Cytotherapy
February 2025
Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China. Electronic address:
Asthma, a prevalent allergic disease affecting approximately 300 million individuals globally, remains a significant public health challenge. Mesenchymal stromal cells (MSCs) and hepatocyte growth factor (HGF), both recognized for their immunomodulatory properties, hold therapeutic potential for asthma. However, their precise mechanisms remain underexplored.
View Article and Find Full Text PDFHow Families Manage the Home Environment for Young People With Asthma and Allergic Sensitisation: A Qualitative Study.
Pediatr Pulmonol
March 2025
Asthma UK Centre for Applied Research, USHER Institute, University of Edinburgh, Edinburgh, UK.
Background And Aim: Children and young people (CYP) with severe, sub-optimally controlled asthma and co-existing allergic senitization to indoor aeroallergens, such as pet dander and house dust mite (HDM), would likely benefit from reduced allergen exposure. Multiple allergen remediation interventions exist and are often suggested to families in secondary care asthma clinics in the United Kingdom. Evidence suggests remediation uptake is low or partial but there is sparse evidence to explain why.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!