Background: Carpometacarpal (CMC) joint dislocations are rare, accounting for less than 1% of all hand injuries. They result from direct high-energy blows to the hand, i.e. falls on the outstretched hand, falls from bicycles or punching one's fist against an object. The objective of this case-series study was to analyse the results of treatment of these injuries in 6 patients who presented to the author's institution.
Material And Methods: In the 3-year period between 2021 and 2023, a total of 6 male patients, mean age of 39 years, with CMC joints dislocations were treated. Three patients had single CMC joint dislocation and the other three had 2 or 3 CMC joints dislocated. Three patients had concomitant fractures of metacarpals or the hamate. Four patients were treated operatively, one conservatively, and one patient with a neglected injury was given physiotherapy. Results were assessed at an average of 16 months post-treatment by a telephone interview in 5 patients.
Results: None of the patients reported pain at rest in his hand and 4 reported mild pain after major loading of the hand. Two patients reported minor pain when the weather changed. Function of the hand as assessed with the quickDASH form was normal. All patients believed that they had fully recovered and all had resumed their pre-injury jobs.
Conclusions: 1. Presented case-series shows satisfactory outcomes of the treatment of CMC joint dislocations, both in isolated injuries and in complex cases. 2. Early diagnosis and rapid reduction of joint dislocations are crucial to regaining proper hand function.
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http://dx.doi.org/10.5604/01.3001.0054.9876 | DOI Listing |
J Immunother Cancer
March 2025
IGM Biosciences, Mountain View, California, USA.
Immunotherapy of cancer is now an essential pillar of treatment for patients with many individual tumor types. Novel immune targets and technical advances are driving a rapid exploration of new treatment strategies incorporating immune agents in cancer clinical practice. Immunotherapies perturb a complex system of interactions among genomically unstable tumor cells, diverse cells within the tumor microenvironment including the systemic adaptive and innate immune cells.
View Article and Find Full Text PDFJ Med Chem
March 2025
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Mas-related G protein-coupled receptor X2 (MrgX2) plays a key role in pseudoallergy reactions; thus, it is of great significance to screen compounds with antipseudoallergy activity via MrgX2. Cell membrane chromatography (CMC) demonstrates great potential in drug screening, but it requires further optimization to improve its specificity and stability. In this study, a new CMC system incorporating His-tag-oriented immobilized proteins was constructed to screen MrgX2 antagonists.
View Article and Find Full Text PDFOrtop Traumatol Rehabil
October 2024
Klinika Chirurgii Ogólnej i Chirurgii Ręki, Pomorski Uniwersytet Medyczny w Szczecinie, Polska / Department of General and Hand Surgery, Pomeranian Medical University in Szczecin, Poland.
Background: Carpometacarpal (CMC) joint dislocations are rare, accounting for less than 1% of all hand injuries. They result from direct high-energy blows to the hand, i.e.
View Article and Find Full Text PDFJ Hand Microsurg
May 2025
Plastic and Reconstructive Surgery, Department of Surgery, Centre Hospitalier de l'Université de Montréal, 1000 Saint-Denis Street, Montreal, Canada.
Nonsurgical therapeutic approaches for thumb carpometacarpal (CMC) osteoarthritis (OA) often offer only inconsistent symptom relief and fail to restore hand function. Intra-articular platelet-rich plasma (PRP) injections have recently emerged as a promising alternative, with encouraging outcomes in knees and hips. This systematic review and meta-analysis aims to highlight the safety and efficacy of PRP injections in thumb CMC OA.
View Article and Find Full Text PDFBMJ Open
March 2025
Teaching, Research and Development, Schulthess Klinik, Zurich, Switzerland.
Purpose: Our hand and forearm registries were established to evaluate safety, function, quality of life and patient satisfaction in patients undergoing thumb and finger implant arthroplasties, as well as corrective osteotomy of the forearm with individual patient solution (IPS) implants.
Participants: Four registries were initiated between 2010 and 2020 and enrolled patients who underwent implant arthroplasties of the thumb carpometacarpal (CMC) joint (n = 486), proximal interphalangeal (PIP) or thumb interphalangeal (IP) joint (n = 864) and metacarpophalangeal (MCP) (n = 34) joint, as well as 27 patients who underwent corrective osteotomy of the distal radius or forearm using an IPS implant. All patients complete disease-specific questionnaires and undergo clinical assessment before surgery (baseline) and up to 10 years thereafter.
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