is a deadly scorpion species found in the tropical regions of the Middle East. Its venom consists of a complex mixture of peptides and enzymes, including the protease toxin hemiscorpius crolysin, the analgesic peptide, and the cytotoxic agent which attacks vascular low-body weight patients, and especially young patients, are prone to systemic complications such as nephrotoxicity, hemolysis, hepatotoxicity, and even death. In this case report, we present a 7-year-old boy from city of Ahwaz in southwestern Iran, who was bitten by Gadeem () and developed hemolytic uremic syndrome. After being stung, the patient developed hemolytic anemia, thrombocytopenia, and uremia in the subsequent days. The patient received supportive treatment, hemodialysis, and plasma exchange, and was discharged after 30 days of hospitalization.
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http://dx.doi.org/10.30699/ijp.2024.2024403.3272 | DOI Listing |
BMC Pediatr
March 2025
Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Nagyerdei Krt 98, 4028, Debrecen, Hungary.
Background: Hemolytic uremic syndrome (HUS), characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury (AKI), remains a leading cause of pediatric AKI. The complement system has a crucial role in the pathogenesis of atypical hemolytic uremic syndrome (aHUS) and eculizumab (ECZ) was approved as standard of care for its treatment. The two widely characterized forms of infection-associated HUS are Shiga toxin-producing E.
View Article and Find Full Text PDFCureus
February 2025
Nephrology, State University of New York Downstate Health Sciences University, Brooklyn, USA.
We present an unusual case of complement-mediated thrombotic microangiopathy (formerly known as atypical hemolytic uremic syndrome) associated with inflammatory disease in a young patient. A 26-year-old male patient with no significant past medical history presented to our emergency department with a four-week history of diffuse, moderate, cramping, non-radiating abdominal pain with no known aggravating or relieving factors. Abdominal pain was associated with nausea, vomiting, and bloody stools.
View Article and Find Full Text PDFPediatrics
March 2025
Department of Pediatrics, Children's Hospital at Montefiore, Bronx, New York.
Germline genetic testing can aid diagnostic workups but may reveal variants of unknown significance (VUS). VUS do not provide definitive diagnoses and may worsen patient and family stress. VUS are more prevalent in populations that are underrepresented in large genomic databases.
View Article and Find Full Text PDFJ Pediatric Infect Dis Soc
March 2025
Kaiser Permanente Northern California Pediatrics, Division Infectious Diseases, San Francisco, CA.
Background: Hemolytic uremic syndrome (HUS) is life-threatening sequelae of Shiga toxin producing Escherichia coli (STEC) enteric infection. To address ambiguity in medical literature, we aimed to identify which STEC toxin profiles and clinical variables were at highest risk of HUS progression to inform evidence-based screening guidelines.
Methods: This was a 5-year retrospective study of children aged <18 years with E.
Iran J Pathol
October 2024
Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
is a deadly scorpion species found in the tropical regions of the Middle East. Its venom consists of a complex mixture of peptides and enzymes, including the protease toxin hemiscorpius crolysin, the analgesic peptide, and the cytotoxic agent which attacks vascular low-body weight patients, and especially young patients, are prone to systemic complications such as nephrotoxicity, hemolysis, hepatotoxicity, and even death. In this case report, we present a 7-year-old boy from city of Ahwaz in southwestern Iran, who was bitten by Gadeem () and developed hemolytic uremic syndrome.
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