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Twists, turns and jumps: T6SS evolution within species.
Trends Microbiol
March 2025
Department of Microbiology, University of Washington, Seattle, WA, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA; Microbial Interactions and Microbiome Center, University of Washington, Seattle, WA, USA. Electronic address:
The type VI secretion system mediates interbacterial antagonism between Gram-negative bacteria through delivery of toxic effector proteins. A recent comprehensive genomic analysis by Habich et al. reveals interesting features of the evolution of T6SSs and their corresponding effectors in Pseudomonas aeruginosa, raising questions about functional specialization of the system.
View Article and Find Full Text PDFBispecific antibody therapy for lymphoma.
Best Pract Res Clin Haematol
December 2024
330 Brookline Ave, Boston, MA, 02215, USA. Electronic address:
The rapid development of novel therapeutics in B-cell Non-Hodgkin's lymphoma (B-NHL) over the past decade has presented a critical inflection point for the field. Bispecific antibodies are one such therapeutic class emerging as an effective, off-the-shelf option for B-NHL. In this review, we focus primarily on Diffuse Large B-cell Lymphoma (DLBCL), highlighting the evolution, comparison, tolerability, ongoing challenges, and future potential of bispecific antibodies that are currently approved or in clinical trials for B-NHL.
View Article and Find Full Text PDFExtracorporeal Membrane Oxygenation in the Treatment of Acute Elemental Mercury Inhalation Toxicity.
Chest
March 2025
Northwell Health Division of Medical Toxicology, North Shore University Hospital, Manhasset, NY.
Inhalation of elemental mercury is a rare cause of ARDS, with limited published case reports to provide guidance regarding disease progression and management. Although extracorporeal membrane oxygenation (ECMO) has been used to treat toxin-induced lung injury, its application to initial treatment and long-term recovery for inhalation of mercury remains undescribed. We present a case of a 56-year-old man who works at a thermometer factory presenting with severe ARDS secondary to inhaled elemental mercury with confirmatory blood and urine mercury levels.
View Article and Find Full Text PDFNanoFlora: Unveiling the therapeutic potential of Ipomoea aquatica nanoparticles.
J Genet Eng Biotechnol
March 2025
Karpagam College of Pharmacy, Coimbatore 641 032 Tamil Nadu, India; The Tamil Nadu Dr. M.G.R. Medical University, Chennai 600032 Tamil Nadu, India. Electronic address:
Introduction: Improving the pharmacokinetics of drugs is achieved through nano formulations and the role of natural product in the synthesis of nanomaterials is gaining prominence due to its eco-friendly nature, cost-effectiveness, and demonstrated efficacy. Metal nanoparticles (NPs) derived from Ipomoea aquatica Forsskal have been synthesized and evaluated for their antioxidant and antidiabetic properties towards enhancing the anticancer activity of the plant extracts.
Methodology: Hydroalcoholic extract was obtained from the entire Ipomoea aquatica plant and utilized as a key ingredient in the green synthesis of metal NPs.
High-throughput screening of natural antiviral drug candidates against white spot syndrome virus targeting VP28 in Penaeus monodon: Computational drug design approaches.
J Genet Eng Biotechnol
March 2025
Department of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh. Electronic address:
The white spot syndrome virus (WSSV), considered the deadliest pathogen impacting Penaeid shrimp (Penaeus monodon), remains worrisome for the global shrimp industry due to its extreme virulence and mortality rate of up to 100%. To date, there has been no breakthrough in effective antivirals or vaccines that can mitigate the financial damage caused by the pathogen. The distinctive structure of VP28 facilitates its role as a trimer, serving as the primary envelope protein of WSSV.
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