Sex Cord Stromal Tumors are rare ovarian tumors, including Steroid Cell tumors, NOS, almost all benign, associated with hirsutism and virilization, with elevated serum testosterone levels, commonly unilateral and with small diameter compared to others. A 43-year-old woman was referred to our center with secondary amenorrhea, hirsutism, balding and clitoromegaly, high serum level of testosterone and free testosterone. Ultrasound examination showed a unilateral small solid rounded hypoechoic lesion, with regular margins, moderately to richly vascularized at power Doppler examination (CS 3/4). A laparoscopic right salpingo-oophorectomy was performed. Final pathology diagnosed a steroid cell tumor, NOS.
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http://dx.doi.org/10.1002/jcu.23945 | DOI Listing |
Sci Transl Med
March 2025
Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.
Interstitial lung disease (ILD) consists of a group of immune-mediated disorders that can cause inflammation and progressive fibrosis of the lungs, representing an area of unmet medical need given the lack of disease-modifying therapies and toxicities associated with current treatment options. Tissue-specific splice variants (SVs) of human aminoacyl-tRNA synthetases (aaRSs) are catalytic nulls thought to confer regulatory functions. One example from human histidyl-tRNA synthetase (HARS), termed HARS because the splicing event resulted in a protein encompassing the WHEP-TRS domain of HARS (a structurally conserved domain found in multiple aaRSs), is enriched in human lung and up-regulated by inflammatory cytokines in lung and immune cells.
View Article and Find Full Text PDFCell Biochem Biophys
March 2025
Georgian National University, 9 Tsinandali Str., Tbilisi, Georgia.
Na,K-ATPase is an electrogenic pump found in cell plasma membranes that acts as the basic unit of animal life. This enzyme is highly susceptible to cardiotonic steroid (CTS) inhibition. The role of Na,K-ATPase in signaling has introduced a novel viewpoint regarding the enzyme's function, as the ouabain-binding site is involved in several physiological processes.
View Article and Find Full Text PDFOral Maxillofac Surg
March 2025
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Bone defects, particularly in the mandible, pose significant clinical challenges due to the limited regenerative capacity. Effective bone tissue engineering requires biomaterials that promote both osteogenesis and angiogenesis. This study developed an optimized collagen-nano hydroxyapatite scaffold loaded with dexamethasone and stem cells to enhance bone regeneration.
View Article and Find Full Text PDFCells
February 2025
Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China.
Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays. The mineralocorticoid receptor (MR) is a classical ligand-activated nuclear transcription factor. It is expressed in the renal intrinsic and immune cells, especially macrophages.
View Article and Find Full Text PDFIntegr Cancer Ther
March 2025
Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chemoresistance is still an important factor affecting the efficacy of treatment in colorectal cancer (CRC) patients. Hypoxia is related to poor prognosis and treatment resistance in cancer. Relevant studies have shown that a hypoxic microenvironment can promote the polarization of M2 macrophages and thus promote tumor development.
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