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Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship between Self-assembly and Cytolytic Activity.
Angew Chem Int Ed Engl
March 2025
Emory University, Chemistry, 1515 Dickey Drive, 30325, Atlanta, UNITED STATES OF AMERICA.
Amphipathic character, encoded within polar sequence patterns of antimicrobial peptides, is a critical structural feature that influences membrane disruptive behavior. Similarly, polar sequence patterns induce self-assembly of amphipathic peptides, which results in the formation of ordered supramolecular structures. The relationship between self-assembly and membrane activity remains an open question of relevance for the development of effective antimicrobial peptides.
View Article and Find Full Text PDFEvaluation of a Simulation Program for Providing Telenursing Training to Nursing Students: Cohort Study.
JMIR Med Educ
March 2025
Department of Nursing, Max Stern Yezreel Valley College, Emek Yezreel, 193000, Israel, 972 523216544.
Background: Telenursing has become prevalent in providing care to diverse populations experiencing different health conditions both in Israel and globally. The nurse-patient relationship aims to improve the condition of individuals requiring health services.
Objectives: This study aims to evaluate nursing graduates' skills and knowledge regarding remote nursing care prior to and following a simulation-based telenursing training program in an undergraduate nursing degree.
UnifiedGreatMod: A New Holistic Modelling Paradigm for Studying Biological Systems on a Complete and Harmonious Scale.
Bioinformatics
March 2025
Department of Computer Science, University of Turin, Torino, 10123, Italy.
Motivation: Computational models are crucial for addressing critical questions about systems evolution and deciphering system connections. The pivotal feature of making this concept recognisable from the biological and clinical community is the possibility of quickly inspecting the whole system, bearing in mind the different granularity levels of its components. This holistic view of system behaviour expands the evolution study by identifying the heterogeneous behaviours applicable, for example, to the cancer evolution study.
View Article and Find Full Text PDFNonmonotonous Translocation Dynamics of Highly Deformable Particles across Channels.
ACS Nano
March 2025
Hefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.
The translocation dynamics of cells and particles through geometric constrictions are critical in biological and biomedical processes from splenic filtration to tumor metastasis. While particle stiffness plays a key role, its role in highly nonequilibrium states remains poorly understood. Here, we present a multiscale model to investigate the impact of particle stiffness on the translocation dynamics in microfluidic channels.
View Article and Find Full Text PDFAgency, sex and drug education: Examining the response-ability of education responses to consumption, sex and harm.
Health (London)
March 2025
Australian Research Centre in Sex, Health and Society, La Trobe University, Australia.
This article examines how drug education professionals understand and respond to the relationship between alcohol and other drug consumption, sex and harm. While recent research examines how these issues are addressed in drug education curriculum, little is known about the perspectives of professionals involved in education design and delivery. Research suggests that agency is centrally important for understanding experiences of harmful, pleasurable or ambiguous sexual encounters in consumption settings.
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