Introduction: Gigantomastia is a rare but not uncommon condition, and the most common surgical reduction procedure is by breast amputation with nipple-areolar grafting. Pedicle-based breast reduction is not commonly undertaken for such conditions.
Aim: This is a report of our experience in the use of an inferior-based pedicle for the reduction of gigantomastia.
Methods: Patients who had reduction mammoplasty between 2004 and 2023 were reviewed. The information obtained from their case notes included age, family history of breast enlargement, presenting features, height, weight, marital status, parity, type of resection, the length of the pedicle, the weight of tissue excised and outcome of the surgery.
Results: A total of 15 patients with gigantomastia were operated. Their age ranged from 16 years to 50 years and a mean of 29.13 ± 9.39 years. The symptoms were: feeling heavy around the chest, back and shoulder pain, not having an appropriate brassiere to wear and lack of self-confidence with low self-esteem The total resection weight (RW) for each patient ranged from 2.2 kg to 10 kg with the mean of 4.71 ± 2.23 kg. The mean body mass index (BMI) was 30.70 ± 9.08 kg/M2, and the average nipple-to-inframammary fold distance was 27.75 ± 6.74 cm on the right and 26.13 ± 5.37 cm on the left. The complications that were observed were delayed wound healing in six (40%), partial wound dehiscence in three (13%), flap necrosis with bilateral loss of nipple-areolar complex (NAC) in one (7%) and unilateral loss of NAC in one (7%). All the patients had good healing with intact NAC except for two patients.
Conclusions: Breast reduction using an inferior pedicle can be one with very good outcomes. The length of the pedicle may be a source of concern for the survival of the NAC using a broad wider base of the pedicle prevents this if properly designed.
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http://dx.doi.org/10.4103/njcp.njcp_427_24 | DOI Listing |
Plast Reconstr Surg Glob Open
March 2025
Surgical Research Group, Netcare Milpark, Johannesburg, South Africa.
Background: Global surgery is a multidisciplinary field that aims to deliver equitable and improved surgical services. Surgical care has been previously considered to play a limited role in the global burden of disease, in part due to its complexity and associated expense. A functional health system mandates high-quality, accessible, and timely surgical care.
View Article and Find Full Text PDFJ Plast Reconstr Aesthet Surg
February 2025
Division of Plastic Surgery, Department of Surgery, Mayo Clinic College of Medicine and Science, Rochester, MN, United States. Electronic address:
Background: The use of drains in reduction mammoplasty is highly variable among plastic surgeons. However, there is limited evidence to guide surgeons on the optimal timing and conditions for using drains to reduce the risk of seroma formation. The objective of this study was to identify factors that predict the possibility of developing postoperative seroma formation.
View Article and Find Full Text PDFBull Cancer
March 2025
Institut Bergonié, service de chirurgie reconstructrice et oncologique, Bordeaux, France.
In France, breast cancer is the most common cancer among women, with 5 to 10% of cases being genetic. Frequently involved genes include BRCA1 and BRCA2, PALB2, TP53, CDH1, and PTEN, among others. Approximately, two in 1000 women carry a BRCA1 or BRCA2 gene mutation.
View Article and Find Full Text PDFCell Rep
February 2025
Chien-Lay Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA; Department of Pathology, UC San Diego, La Jolla, CA 92093, USA; Department of Surgery, UC San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, UC San Diego, La Jolla, CA 92093, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA. Electronic address:
Although only a fraction of tumor cells contribute to metastatic disease, no prognostic biomarkers currently exist to identify these cells. We show that a physical marker-adhesion strength-predicts metastatic potential in a mouse breast cancer model and that it may stratify human disease. Cells disseminating from murine mammary tumors are weakly adherent, and, when pre-sorted by adhesion, primary tumors created from strongly adherent cells exhibit fewer lung metastases than weakly adherent cells do.
View Article and Find Full Text PDFJ Wound Care
March 2025
Department of Vascular Surgery, Norfolk & Norwich University Hospital, Norwich, UK.
Objective: Dermabond Prineo (Ethicon Inc., US) is a combination of a skin adhesive applied over a polyester mesh to reinforce and share tension equally over the surgical wound with the aim of reducing closure time and improving wound healing. The aims of this systematic review were to assess published data on Dermabond Prineo regarding infection rates, delayed wound healing, cosmetic appearance and application time compared to conventional wound closure techniques across multiple surgical procedures.
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