Aims: Emergency department (ED) revisits within 72 h is a standard quality measure for emergency care but most revisits are managed and discharged. However, a sub-group of revisits are due to clinical deterioration resulting in admissions to higher acuity care or even mortality. We aimed to identify these critical revisits and their associated risk factors. Identification of these factors would allow development of strategies to reduce incidence of post discharge deterioration.
Methods: A retrospective cohort study was conducted on all patients who had a revisit within 72 h of discharge from the ED of a tertiary hospital in Singapore from 2008 to 2020. Deidentified data were extracted from the electronic health records (EHR). We identified critical revisits, defined as a revisit that resulted in death or admission to Intensive Care Unit or High Dependency. These patients were compared to patients who had a revisit that resulted in discharge or admission to general ward. The main outcome was the rate of critical revisit. We also determined the commonest index and critical revisit ED diagnosis as well as factors associated with critical revisits.
Results: Out of 1,057,533 discharges from the ED over the study period, 44,506 (4.2%) had a revisit within 72 h, of which 1321 (0.12%) were critical revisits. Adjusted odds ratios from multivariable logistic regression analysis indicated that higher heart rate, higher mean arterial pressure, and several lab abnormalities were associated with critical revisits. Diagnosis categories at the initial visit with the highest contribution to the likelihood of a critical revisit included "acute cerebrovascular disease" (OR: 38.00, 95%CI: 27.04-53.39), "other gastrointestinal disorders" (OR: 3.10, 95%CI: 2.41-3.99) and "residual codes; unclassified" (OR: 2.69, 95%CI: 2.01-3.60).
Conclusion: Critical revisits after discharge were rare in our study population, most prevalent amongst the elderly with multiple comorbidities. Future research should focus on diagnoses at higher risk of a critical revisit to develop practical approaches to follow up these patients.
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http://dx.doi.org/10.1186/s12245-025-00847-x | DOI Listing |
J Exp Bot
March 2025
Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.
Plant metabolism is profoundly affected by various abiotic stresses. Consequently, plants must reconfigure their metabolic networks to sustain homeostasis while synthesizing compounds that mitigate stress. This aspect, with the current intensified climate impact results in more frequent abiotic stresses on a global scale.
View Article and Find Full Text PDFMotivation: Protein side-chain packing (PSCP), the problem of predicting side-chain conformation given a fixed backbone structure, has important implications in modeling of structures and interactions. However, despite the groundbreaking progress in protein structure prediction pioneered by AlphaFold, the existing PSCP methods still rely on experimental inputs, and do not leverage AlphaFold-predicted backbone coordinates to enable PSCP at scale.
Results: Here, we perform a large-scale benchmarking of the predictive performance of various PSCP methods on public datasets from multiple rounds of the Critical Assessment of Structure Prediction (CASP) challenges using a diverse set of evaluation metrics.
Am J Cardiovasc Drugs
March 2025
Department of Cardiology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, UP, 226014, India.
The results of the recently concluded ULTIMATE-DAPT and T-PASS trials strongly support the emerging concept of antiplatelet monotherapy in patients at high bleeding risk undergoing percutaneous coronary intervention. Monotherapy with more potent antiplatelets such as ticagrelor is both a safe and an equally effective strategy to circumvent major bleeding episodes in patients at high bleeding risk while guarding against ischemic events. Although these results were not replicated with low-dose prasugrel monotherapy in the STOP-DAPT-3 trial, the other major trials investigating ticagrelor monotherapy (GLOBAL-LEADERS and TWILIGHT-ACS) suggested the feasibility and appropriateness of abbreviating the dual antiplatelet therapy (DAPT) as early as 1-3 months of the index procedure.
View Article and Find Full Text PDFOncogene
March 2025
Department of Radiation Oncology, University of California Davis, Sacramento, California, USA.
Disrupted cellular polarity (DCP) is a hallmark of solid cancer, the malignant disease of epithelial tissues, which occupies ~90% of all human cancers. DCP has been identified to affect not only the cancer cell's aggressive behavior but also the migration and infiltration of immune cells, although the precise mechanism of DCP-affected tumor-immune cell interaction remains unclear. This review discusses immunosuppressive tumor microenvironments (TME) caused by DCP-driven tumor cell proliferation with DCP-impaired immune cell functions.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Civil Engineering, Sharif University of Technology, Tehran, Iran.
Evapotranspiration is a key component of the hydrological cycle, influencing water and biogeochemical cycles in the critical zone. Particularly, the travel time of evapotranspired water is critical for describing the origin and young water contribution to evapotranspiration, but is yet poorly understood. In this study, we revisited the Lagrangian particle-tracking model, EcoSLIM, to separate evaporation and transpiration particles using a mass balance approach.
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