To investigate the internal flow mechanisms during cavitation in self-priming pumps, this study employs numerical simulations based on the RNG k-ε turbulence model coupled with the Schnerr-Sauer cavitation model. The vapor-liquid two-phase flow characteristics at the critical cavitation condition are analyzed under various flow rates and rotational speeds. Based on the vorticity method, Q criterion, λ criterion, Δ criterion, λ criterion, and Ω criterion, predictions and comparative analyses of the vortex structures during cavitation in self-priming pumps have been conducted. Additionally, the energy loss in various regions of the pump before and after cavitation onset has been analyzed using the theory of entropy production. The results demonstrate that the Ω criterion, Q criterion, and λ criterion yield consistent vortex identification outcomes across different regions. In contrast, the Δ criterion and λ criterion produce more fragmented vortices, most notably in the gas-liquid separation chamber area, whereas the vorticity method is most susceptible to disturbances from strong shear layers; Energy losses are not directly related to vorticity but show a significant correlation with vortex intensity; Changes in flow rate and the onset of cavitation have the greatest impact on average entropy production in the reflux hole region, particularly under high flow conditions; The difference in energy loss of the impeller is the largest before and after cavitation occurs; When the cavitation coefficient is constant, the vapor volume fraction in the impeller region exhibits a positive correlation with both flow rate and rotational speed.
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http://dx.doi.org/10.1038/s41598-025-85662-3 | DOI Listing |
J Biopharm Stat
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Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Evaluation.
Conventionally, the product quality specification and control chart limits are determined as the mean plus and minus 3 sample standard deviations with the assumption that the quality data is normally distributed. These limits correspond to an interval centered at the mean, covering approximately 97.3% of the population.
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Center for the Acceleration of Harm Reduction, University of Catania, Catania, Italy.
E-cigarettes (ECs) are a well-established consumer product. To study their respiratory health effects, there is the issue of heterogenous patterns of use: concurrently with cigarette smoking (dual use), exclusive use after smoking cessation (exclusive use), or use initiated without any prior or current use of cigarettes (naïve use). Our primary goal was to synthesize the evidence on the respiratory effects of ECs use in adults, categorized by their pattern of use.
View Article and Find Full Text PDFAnesth Pain Med
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School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: Intraoperative bleeding is one of the major challenges in rhinoplasty.
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Methods: In a double-blinded randomized clinical trial, 58 candidates for rhinoplasty were randomly assigned to the PCV or VCV groups.
Front Pharmacol
February 2025
Department of Drug Discovery and Development, GenFleet Therapeutics (Shanghai) Inc., Shanghai, China.
Introduction: The cytochrome P450 enzyme 3A4 (CYP3A4) mediates numerous drug-drug interactions (DDIs) by inducing the metabolism of co-administered drugs, which can result in reduced therapeutic efficacy or increased toxicity. This study developed and validated a Physiologically Based Pharmacokinetic (PBPK) model to predict CYP3A4 induction-mediated DDIs, focusing on the early stages of clinical drug development.
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Front Oncol
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