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Vulvar Cellular Angiofibroma With Cytologic Atypia and Sarcomatous Transformation: A Clinicopathologic Analysis.
Int J Gynecol Pathol
March 2025
Emory University Hospital, Atlanta, GA.
Cellular angiofibromas (CAFs) are benign mesenchymal neoplasms of the vulva and lower genitourinary tract. Although most cases are benign with excellent prognosis, data on CAFs with cytologic atypia (aCAF) and sarcomatous transformation (tCAF) is limited. We identified 13 vulvar CAFs comprising 4 aCAFs and 9 tCAFs.
View Article and Find Full Text PDFLST1 expression correlates with immune infiltration and predicts poor prognosis in acute myeloid leukemia.
Discov Oncol
March 2025
Department of Hematology, Anqing Municipal Hospital, Anqing Hospital Affiliated to Anhui Medical University, Anqing, China.
Clinical management of acute myeloid leukemia (AML) poses significant challenges due to its poor prognosis and heterogeneous nature. Discovering new biomarkers is crucial for improving risk assessment and customizing treatment approaches. While leukocyte-specific transcript 1 (LST1) is implicated in inflammation and immune regulation, its function in AML remains ambiguous.
View Article and Find Full Text PDFRisk Prediction Models for Sentinel Node Positivity in Melanoma: A Systematic Review and Meta-Analysis.
JAMA Dermatol
March 2025
Department of Surgery, Arthur J.E. Child Comprehensive Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
Importance: There is a need to identify the best performing risk prediction model for sentinel lymph node biopsy (SLNB) positivity in melanoma.
Objective: To comprehensively review the characteristics and discriminative performance of existing risk prediction models for SLNB positivity in melanoma.
Data Sources: Embase and MEDLINE were searched from inception to May 1, 2024, for English language articles.
Nodular Goitre Posing as a Follicular Carcinoma with Extrathyroidal Extension: A Diagnostic Dilemma - A Case Report.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Surgical Oncology, Yashoda Hospitals, Hitec City, Hyderabad, Telangana India.
Nodular goitre caused by thyroid hyperplasia is a benign condition arising from abnormalities in thyroid gland physiology, resulting from an imbalance between thyroid-stimulating hormone, thyrotropin-releasing hormone, and the follicular epithelium of the thyroid gland. The histopathological characteristics of this hyperplasia can resemble well-differentiated follicular carcinoma of the thyroid. Here, we present the case of a 66-year-old man with clinicopathological features suggestive of follicular carcinoma with extrathyroidal extension.
View Article and Find Full Text PDFPrediction of post‑nephroureterectomy renal function in non‑dialysis upper tract urothelial carcinoma using machine learning with PyCaret and SHAP explanations.
Oncol Lett
April 2025
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C.
Renal function after radical nephroureterectomy (RNU) in patients with advanced upper tract urothelial carcinoma (UTUC) is an indicator of eligibility for postoperative chemotherapy. The present study aimed to utilize machine learning for predicting renal function status after RNU and to investigate the contribution of several features to this prediction. The present retrospective study included 764 medical records of patients with non-metastatic UTUC who received RNU from 2008 to 2022.
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