Phyllodes tumors (PT) of the breast is a rare fibroepithelial tumor, which can be divided into benign, borderline and malignant pathological types according to its histological characteristics. Malignant phyllodes tumor (MPT) accounts for 10%-20% of PT and has the ability of local recurrence and distant metastasis. Therefore, accurate diagnosis and identification of MPT are particularly important for patients to obtain appropriate treatment at the initial diagnosis. At present, histological morphology is the only diagnostic basis for MPT. However, due to the fact that phyllode tumor itself is a continuous disease spectrum with overlapping histological features, and the diagnostic classification adopts many histological parameters and their evaluation is subjective, pathologists lack consistency in MPT grading, and the biological behavior of PT is not completely consistent. Therefore, the existing MPT classification standards are facing challenges, and the accurate and reproducible classification is worthy of further exploration.
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http://dx.doi.org/10.3760/cma.j.cn112151-20241225-00871 | DOI Listing |
Unlabelled: İntroduction: The aim of this study was to assess the contribution of voice therapy to management of patients following surgery for vocal fold polyps.
Methods: In this prospective study, two groups were created by randomizing patients diagnosed with vocal fold polyps. Group 1 received only phonosurgery, and Group 2 received phonosurgery followed by voice therapy.
Int J Pharm
March 2025
School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK. Electronic address:
A dapivirine (DPV)-releasing vaginal ring (DapiRing®, containing 25 mg DPV) has been approved in various African countries for prevention of human immunodeficiency virus type 1 (HIV-1). Current research is focused on next-generation multipurpose prevention technology (MPT) vaginal rings that additionally provide contraception, and a combination dapivirine + levonorgestrel ring is in clinical development. However, hormonal contraceptives have numerous side effects and contraindications, and many women are interested in hormone-free contraceptive options.
View Article and Find Full Text PDFLymph nodes are highly specialized immune organs that orchestrate the adaptive immune response. In the lymph nodes, naïve B and T lymphocytes encounter cognate antigens, sparking their activation and response to foreign substances. Lymph nodes grow in response to an immune challenge, at least in part to accommodate increased numbers of infiltrating and proliferating B and T lymphocytes.
View Article and Find Full Text PDFJ Drug Target
March 2025
Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Background: Malignant phyllodes tumors (MPT) of the breast are rare fibroepithelial neoplasms. It exhibits rapid growth, large size, and a high local recurrence rate.
Methods: In this study, we established novel patient-derived organoid (PDO) models from two primary MPT samples and conducted comprehensive genetic profiling and drug screening.
J Voice
March 2025
Pontifícia Universidade Católica de São Paulo (PUCSP), São Paulo, Brazil.
Objective: To associate different methods of measuring maximum phonation time (MPT) according to sex and body mass index (BMI).
Methods: The study included 30 men and 30 women aged between 18 and 45years. Four different methods of measuring MPT were tested, and the obtained values were compared between sexes and BMI.
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