This case report describes the treatment process of a severe exertional heat stroke-induced coagulopathy in a 20-year-old firefighter. Through a comprehensive treatment strategy of five early and one prevention, including early cooling, early anticoagulation, early coagulation factor supplementation, early anti-inflammation, early blood purification, and prevention of complications, the patient was successfully treated. For the management of heat stroke-induced coagulopathy, based on the coagulation rebalancing strategy-namely anticoagulation combined with goal-directed replacement therapy, along with plasma diafiltration (PDF) treatment-the patient's coagulation function was effectively improved without any bleeding or thrombotic events. The patient's coagulation function returned to normal by day 4 of hospitalization, the tracheal tube was removed on day 6, transferred to the general ward after 11 days, and was discharged after 21 days of rehabilitation.
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http://dx.doi.org/10.3760/cma.j.cn121090-20241211-00557 | DOI Listing |
Zhonghua Xue Ye Xue Za Zhi
December 2024
Department of Critical Care Medicine, the 908th Hospital of Joint Logistics Support Forces of Chinese PLA, Nanchang 330002, China.
This case report describes the treatment process of a severe exertional heat stroke-induced coagulopathy in a 20-year-old firefighter. Through a comprehensive treatment strategy of five early and one prevention, including early cooling, early anticoagulation, early coagulation factor supplementation, early anti-inflammation, early blood purification, and prevention of complications, the patient was successfully treated. For the management of heat stroke-induced coagulopathy, based on the coagulation rebalancing strategy-namely anticoagulation combined with goal-directed replacement therapy, along with plasma diafiltration (PDF) treatment-the patient's coagulation function was effectively improved without any bleeding or thrombotic events.
View Article and Find Full Text PDFInt J Hyperthermia
December 2025
Department of Public Health, Ningxia Medical University, Yinchuan City, Ningxia Province, China.
Objective: Cardiovascular injury is a common complication of heat stroke (HS). However, the mechanism underlying vascular smooth muscle cells (VSMCs) following HS remains unclear.
Method: A rat and VSMCs model was established by simulating high-temperature exposure.
Front Pharmacol
January 2025
Heat Stroke Treatment and Research Center of Chinese PLA General Hospital, Sanya, China.
Exertional heat stroke (EHS) is a life-threatening condition characterized by hyperthermia and multi-organ dysfunction, often associated with intestinal barrier disruption. This study evaluated the protective effects of Huoxiang Zhengqi Dropping Pills (HXZQD) against EHS in a rat model. HXZQD was administered via oral gavage at low, medium, and high doses, followed by EHS induction through exercise under high-temperature and high-humidity conditions.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
November 2024
Department of Pulmonary and Critical Care Medicine, The 987th Hospital of Joint Logistics Support Force of Chinese PLA, Baoji, 721000, China.
Background: Heat stroke (HS) can lead to the development of pulmonary ferroptosis. The inhibition of pulmonary ferroptosis during HS improves patient prognosis. The aim of this study was to investigate the effects of resveratrol (RES) on heat stress at an ambient temperature of 42 °C.
View Article and Find Full Text PDFInt Immunopharmacol
December 2024
Department of Intensive Care Unit, Ningbo No.2 Hospital, Ningbo 315010, China. Electronic address:
Heatstroke is a critical condition with a high mortality rate and intestinal barrier dysfunction is a key factor in its progression to sepsis in some patients. This study aimed to explore the protective effects of rifaximin on the intestinal barrier in heat-stroke mice and the underlying mechanisms. A mouse model of heat stroke was established, followed by rifaximin intervention.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!