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The adoption of virtual patients promises to revolutionize pharmaceutical R&D and health care through more patient-centric approaches and is driven by integrating innovations in computational approaches, AI, and advanced in vitro human model systems. Virtual patients can create the conditions for faster and more predictive R&D, affecting all drivers of R&D productivity. Virtual patients enable personalized health care, ensuring precise drug dosing and scheduling to maximize efficacy and minimize adverse effects. Numerous concrete examples demonstrate the transformative potential of virtual patients in real-world scenarios, showcasing significant improvements in drug development and clinical outcomes. Despite challenges in data variability, regulatory compliance, and data privacy, virtual patients hold immense potential to transform R&D and clinical practices, driving a new era of personalized and efficient R&D and health care.
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http://dx.doi.org/10.1016/j.drudis.2025.104322 | DOI Listing |
Sci Rep
March 2025
Division of Pain Medicine, Department of Anesthesiology, Roswell Park Comprehensive Cancer Center, Buffalo, 14263, USA.
Objective measurements of pain and safe methods to alleviate it could revolutionize medicine. This study used functional near-infrared spectroscopy (fNIRS) and virtual reality (VR) to improve pain assessment and explore non-pharmacological pain relief in cancer patients. Using resting-state fNIRS (rs-fNIRS) data and multinomial logistic regression (MLR), we identified brain-based pain biomarkers and classified pain severity in cancer patients.
View Article and Find Full Text PDFComput Biol Med
March 2025
Intravides SRL, Via Cristoforo Colombo, 1, Torino, 10124, Italy; Department of Neuroscience "Rita Levi Montalcini", Università degli Studi di Torino, Corso Massimo D'Azeglio, 52, Torino, 10126, Italy; Neuroscience Institute Cavalieri Ottolenghi, Regione Gonzole 10, Orbassano (TO), Italy. Electronic address:
Purpose: Minimally invasive surgery (MIS) has emerged in clinical practice to minimize surgical trauma, providing patients with faster recovery, reduced pain and complications and enhanced aesthetic results compared to traditional surgery. However, this approach increase the risk of iatrogenic damage, i.e.
View Article and Find Full Text PDFNurse Educ Today
March 2025
College of Nursing, Kosin University, Seo-gu, Busan, Republic of Korea. Electronic address:
Aims: Patient safety is a global concern, and nurses, as the largest group of healthcare professionals, play a critical role in ensuring patient safety. This study aimed to systematically review and analyze the effects of patient safety education programs on nursing students' knowledge, attitudes, and competencies by synthesizing existing research and identifying key factors contributing to program effectiveness.
Design: Systematic review and meta-analysis.
Nurs Res
March 2025
Jinan University, School of Nursing, Guangzhou, Guangdong, China.
Background: Gamification uses game-based mechanics, aesthetics, and game thinking to engage people, motivate action, promote learning, and solve problems. However, gaps remain in understanding and implementing gamification in rehabilitation care, necessitating further exploration and clarification of the best evidence for application of gamification.
Objective: To conduct a scoping review of the use of gamification in rehabilitation care for adults with chronic illnesses, summarizing the scope, forms, elements, guiding theories, effectiveness, and ease of use of gamification.
Biomark Res
March 2025
Department of Bioinformatics, Semmelweis University, Tűzoltó U. 7-9, Budapest, 1094, Hungary.
Artificial intelligence (AI) can transform drug discovery and early drug development by addressing inefficiencies in traditional methods, which often face high costs, long timelines, and low success rates. In this review we provide an overview of how to integrate AI to the current drug discovery and development process, as it can enhance activities like target identification, drug discovery, and early clinical development. Through multiomics data analysis and network-based approaches, AI can help to identify novel oncogenic vulnerabilities and key therapeutic targets.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!