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Statistical inference on change points in generalized semiparametric segmented models.
Biometrics
January 2025
Vanke School of Public Health, Tsinghua University, Beijing, 100084, China.
The segmented model has significant applications in scientific research when the change-point effect exists. In this article, we propose a comprehensive semiparametric framework in segmented models to test the existence and estimate the location of change points in the generalized outcome setting. The proposed framework is based on a semismooth estimating equation for the change-point estimation and an average score-type test for hypothesis testing.
View Article and Find Full Text PDFEnablers and Barriers to an Experience-Based Co-Design Process to Develop Service Improvements in Enhanced Community Care in Ireland: A Qualitative Study.
Health Expect
April 2025
Department of Psychology, University of Limerick, Limerick, Ireland.
Background: Experience-Based Co-Design (EBCD) is a popular collaborative process where service users and healthcare providers share their experiences of using and delivering services to identify ways to adapt services to enhance those experiences.
Objective: This study aimed to identify enablers and barriers to the successful implementation of EBCD as part of Ireland's recently adopted Enhanced Community Care (ECC) programme.
Design: Service users and staff at two sites (N = 17) participated in an accelerated EBCD process designed to enhance service provision for older people and those living with chronic conditions.
Biological Effects of Micro-/Nano-Plastics in Macrophages.
Nanomaterials (Basel)
March 2025
Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy.
The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence of micro- (MPs) and nanosized (NPs) plastic particles. MPs and NPs are thus widely present in water and air and inevitably enter the food chain, with inhalation and ingestion as the main exposure routes for humans. Many recent studies have demonstrated that MPs and NPs gain access to several body compartments, where they are taken up by cells, increase the production of reactive oxygen species, and lead to inflammatory changes.
View Article and Find Full Text PDFFinerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy.
Cells
February 2025
Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China.
Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays. The mineralocorticoid receptor (MR) is a classical ligand-activated nuclear transcription factor. It is expressed in the renal intrinsic and immune cells, especially macrophages.
View Article and Find Full Text PDFClimate change and gendered vulnerability: A systematic review of women's health.
Womens Health (Lond)
March 2025
Department of Psychology, University of Limerick, Limerick, Ireland.
Background: Climate change is an urgent global threat, with women in low- and middle-income countries (LMICs) disproportionately facing adverse health outcomes. Gendered roles, combined with socioeconomic, cultural, and environmental factors, exacerbate women's vulnerabilities, increasing the burden of mental health issues, water insecurity, sanitation challenges, and caregiving responsibilities.
Objectives: This review seeks to systematically examine the intersection between climate change and gendered health vulnerabilities, with a particular focus on women.
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