Transient acoustic holography is a useful technique for characterization of ultrasound transducers. It involves hydrophone measurements of the 2-D distribution of acoustic pressure waveforms in a transverse plane in front of the transducer - a hologram - and subsequent numerical forward or backward projection of the ultrasound field. This approach enables full spatiotemporal reconstruction of the acoustic field, including the vibrational velocity at the transducer surface. This allows identification of transducer defects as well as structural details of the radiated acoustic field such as side lobes and hot spots. However, numerical projections may be time-consuming (1010 - 1011 operations with complex exponents). Moreover, back-projection from the measurement plane to the transducer surface is sensitive to misalignment between the axes of the positioning system and the axes associated with the transducer. This paper presents an open access transducer characterization toolbox for use in MATLAB or Octave on Windows computers (https://github.com/pavrosni/xDDx/releases). The core algorithm is based on the Rayleigh integral implemented in C++ executables for graphics and central processing units (GPUs and CPUs). The toolbox includes an automated procedure for correcting axes misalignments to optimize the visualization of transducer surface vibrations. Beyond using measured holograms, the toolbox can also simulate the fields radiated by user-defined transducers. Measurements from two focused 1.25-MHz 12-element sector transducers (apertures of 87 mm, focal distances of 65 mm and 87 mm) were used with the toolbox for demonstration purposes. Simulation speed tests for different computational devices showed a range of 0.2 s - 3 min for GPUs and 1.6 s - 57 min for CPUs.
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http://dx.doi.org/10.1109/TUFFC.2025.3542405 | DOI Listing |
Ultrasonics
March 2025
Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, PR China. Electronic address:
Cells' ability to sense and respond to mechanical stimuli is fundamental to various biological processes and serves as a crucial biomarker of their physiological and pathological states. Traditional methods for assessing cell mechanical properties, such as atomic force microscopy and micropipette aspiration, are hindered by complex procedures and the risk of cellular damage due to direct contact. Here we introduce a novel non-contact acoustic squeezer that leverages focused interdigital transducers to induce cell deformation through a robust standing surface acoustic wave (SSAW) field.
View Article and Find Full Text PDFFront Bioeng Biotechnol
February 2025
Brain Tumor Center & Neuro-Oncology Unit, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Purpose: Tumor Treating Fields (TTFields) are delivered by transducer arrays applied to scalp or body surface for treatment of multiple malignancies. Dermatologic complications are thought to be related to hydrogel situated between the electrodes and scalp or skin to facilitate electric field penetration. High intensity of TTFields on these surfaces may also be a contributing factor.
View Article and Find Full Text PDFACS Sens
March 2025
Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
The surface-induced ordering of liquid crystals (LC) has been harnessed to detect a wide range of chemical and biological stimuli. In most sensor designs, the information-rich response of the LC is transduced from an analyte-triggered change in the out-of-plane orientation of the LC. Quantifying the out-of-plane LC orientation, however, is often complicated by simultaneous changes in the in-plane orientation of the LC when using polarized light for transduction.
View Article and Find Full Text PDFAnn Biomed Eng
March 2025
Biomedical Instrumentation Lab, Department of Mechanical Engineering, University of Alberta, Edmonton, Canada.
Physical surrogates of the human head are commonly used to model cranial impacts, assess helmet efficacy and assess likelihood of head injuries. The Brain Injury Protection Evaluation Device (BIPED mk2) is a head form that contains a brain simulant, cerebrospinal fluid layer (CSF), connective membranes, a skull and a skin layer, and can be configured to measure kinematics, pressures and strains. In design efforts to increase the biofidelity of surrogates, finite element models play a significant role in assessing design iterations that better mimic the biological response of the head during impact.
View Article and Find Full Text PDFNeuron
March 2025
New Cornerstone Science Laboratory, IDG/McGovern Institute of Brain Research, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, P.R. China; Chinese Institute for Brain Research, Beijing, P.R. China. Electronic address:
Primary cilia are cellular antennae emanating from vertebrate cell surfaces to sense and transduce extracellular signals intracellularly to regulate cell behavior and function. However, their signal sensing and physiological functions in neocortical neurons remain largely unclear. Here, we show that, in response to various animal stressors, primary cilia in the mouse prefrontal cortex (PFC) exhibit consistent axonemal elongation.
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