IEEE Trans Neural Netw Learn Syst
Published: February 2025
In this article, we attempt to study a problem of identifying outliers from multiple dimensions, terming it as multidimensional anomaly detection. This task assumes that each sample corresponds to heterogeneous discriminative spaces, where each space characterizes distinct semantic information along one dimension. Consequently, the abnormalities exhibited by a sample will vary under these semantically different dimensions. In contrast to traditional anomaly detection, multidimensional anomaly detection offers a more holistic assessment of a sample's abnormalities. However, the heterogeneity of discriminative spaces leads to incomparability of the outputs from different dimensions which is the major difficulty in designing multidimensional anomaly detection methods. This article introduces a novel model, maximum margin multidimensional anomaly detection (ALOE), specifically tailored for multidimensional anomaly detection. ALOE constructs a convex optimization problem with nonlinear constraints. The primary objective is to simultaneously learn multiple decision boundaries, utilizing the maximum margin principle and covariance regularization, while distinguishing between outliers and normal samples under multiple dimensions by capturing the correlation among multiple dimensions. To obtain the optimal decision boundary under each dimension, we devise an alternating optimization method for this convex optimization problem. To validate the effectiveness of ALOE, we conduct extensive experiments on 12 real-world datasets, comparing its performance against 34 anomaly detection methods. The experimental results demonstrate the superior performance of ALOE.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1109/TNNLS.2025.3540602 | DOI Listing |
Front Neurosci
February 2025
Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition in urology characterized by chronic pain. The pathogenesis of CP/CPPS remains unclear.
Methods: We enrolled 45 eligible CP/CPPS patients and 45 healthy volunteers.
Cureus
February 2025
Gastroenterology and Hepatology, Nazareth Hospital Edinburgh Medical Missionary Society (EMMS), Nazareth, ISR.
Esophageal symptoms, including dysphagia, heartburn, and non-cardiac chest pain, are prevalent concerns in gastroenterology. This review examines the roles of advanced diagnostic modalities such as high-resolution manometry (HRM), pH-impedance monitoring, and EndoFLIP in understanding esophageal physiology and pathology. Here, we discuss the clinical presentations of common esophageal symptoms and explore how structural abnormalities like strictures and motility disorders, including achalasia and esophageal spasms, are assessed using these tools.
View Article and Find Full Text PDFMol Genet Genomic Med
March 2025
Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
Background: Whole exome sequencing (WES) aids in diagnosing monogenic diseases, yet > 50% of all cases remain undiagnosed. We aimed to improve diagnostic precision by developing an effective WES-based strategy for detecting congenital anomalies.
Methods: Initially, 128 probands with congenital anomalies were assessed using trio-WES and copy number variation analysis-variant interpretation was for exons and splice sites.
Clin Shoulder Elb
March 2025
Department of Orthopaedics and Traumatology, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia.
Background: Accurate pathoanatomic diagnosis of the cause of shoulder pain cannot rely solely on clinical tests. Similarly, diagnosis based on imaging results alone is not reliable due to the high prevalence of asymptomatic pathology. This study aims to assess the diagnostic accuracy of clinical testing with lidocaine injection and ultrasonography as a screening method for detecting supraspinatus disorders compared with magnetic resonance imaging (MRI).
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Neonatal Congenital Heart Laboratory, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
One out of every hundred live births present with congenital heart abnormalities caused by the aberrant development of the embryonic cardiovascular system. The conserved zinc finger transcription factor proteins, which include GATA binding protein 5 (GATA5) and GATA binding protein (GATA6) play important roles in embryonic development and their inactivation may result in congenital heart defects (CHDs). In this study, we performed genotypic-phenotypic analyses in two families affected by right-sided CHD diagnosed by echocardiography imaging.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.