Digital image forensics plays a crucial role in image authentication and manipulation localization. Despite the progress powered by deep neural networks, existing forgery localization methodologies exhibit limitations when deployed to unseen datasets and perturbed images (i.e., lack of generalization and robustness to real-world applications). To circumvent these problems and aid image integrity, this paper presents a generalized and robust manipulation localization model through the analysis of pixel inconsistency artifacts. The rationale is grounded on the observation that most image signal processors (ISP) involve the demosaicing process, which introduces pixel correlations in pristine images. Moreover, manipulating operations, including splicing, copy-move, and inpainting, directly affect such pixel regularity. We, therefore, first split the input image into several blocks and design masked self-attention mechanisms to model the global pixel dependency in input images. Simultaneously, we optimize another local pixel dependency stream to mine local manipulation clues within input forgery images. In addition, we design novel Learning-to-Weight Modules (LWM) to combine features from the two streams, thereby enhancing the final forgery localization performance. To improve the training process, we propose a novel Pixel-Inconsistency Data Augmentation (PIDA) strategy, driving the model to focus on capturing inherent pixel-level artifacts instead of mining semantic forgery traces. This work establishes a comprehensive benchmark integrating 16 representative detection models across 12 datasets. Extensive experiments show that our method successfully extracts inherent pixel-inconsistency forgery fingerprints and achieve state-of-the-art generalization and robustness performances in image manipulation localization.
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http://dx.doi.org/10.1109/TPAMI.2025.3541028 | DOI Listing |
Infect Immun
March 2025
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
is a gram-negative, obligate intracellular pathogen that causes human Q fever. Within host cells, proliferates in a spacious, acidic, lysosome-derived -containing vacuole (CCV) by a process that requires the Dot/Icm type IVB secretion system to deliver effectors that manipulate host cell functions. A previous transposon mutagenesis screen identified the gene as being important for intracellular replication of .
View Article and Find Full Text PDFJ Virol
March 2025
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Porcine epidemic diarrhea virus (PEDV) is a primary cause of viral diarrhea in neonatal piglets, leading to substantial economic losses in the swine industry globally. It primarily targets epithelial cells of the small intestine, compromising intestinal function and resulting in the death of affected animals. As mitochondria are essential for maintaining gut health, this study investigates the effects of PEDV infection on mitochondrial function in small intestinal epithelial cells and its subsequent impacts.
View Article and Find Full Text PDFJ Dent Res
March 2025
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore. Center to Advance Chronic Pain Research, Baltimore, MD, USA.
Multiple sensory afferents, including mechanosensitive and nociceptive nerves, are projected to the periodontium. Peptidergic afferents expressing transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin, mediate pain caused by orthodontic forces. However, their role in orthodontic force-induced alveolar bone remodeling is poorly understood as is the contribution of mechanosensitive ion channels such as Piezo2 in nociceptive nerves.
View Article and Find Full Text PDFBackground: Male factor infertility (MFI) is responsible for 50% of infertility cases and in 15% of the cases sperm is absent due to germ cell aplasia. Human induced pluripotent stem cell (hiPSC)-derived spermatogonial stem cells (hSSCs) could serve as an autologous germ cell source for MFI in patients with an insufficient sperm yield for assisted reproductive technology (ART). The endocannabinoid system (ECS) has been implicated to play a role in mouse embryonic stem cells (mESCs) and the human testicular environment.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
March 2025
Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, Aarhus C 8000, Denmark. Electronic address:
Hydrogel biomaterials have been extensively explored for applications in medicine, materials science, and the development of functionalized materials. Traditionally, hydrogels were produced using simple polymers, but advancements over recent decades have enabled the use of biological materials such as proteins, peptides, polysaccharides, and even amyloid fibrils. Among these, amyloid-based hydrogels have demonstrated unique advantages, including enhanced cell adhesion and differentiation.
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