To improve the performance of object recognition under artificial prosthetic vision, this study proposes a two-stage method. The first stage is to extract the saliency and edge Mask of the object (SMP, EMP). Then, the irregular visual information of the object is processed using Irregularity Correction (IC). We design eye-hand coordination tasks and simulate artificial vision with retinal prostheses to validate strategy effectiveness, and select direct pixelation (DP) as a control group. Each subject retained a phosphene map in the same stochastic pattern in all his/her trails. The real-time experimental results showed that the deep saliency-based optimization strategies improved the performance of the subjects when completing tasks, in terms of head movement, recognition accuracy, and response time, and counts for successful small-objects recognition. The subjects have the smallest-scale average head movement (76.53 deg ± 20.75 deg), higher average objects recognition accuracy (91.18% ± 2.52%), and less time for finishing the task (35.71 s ± 8.66 s) and better successful search times of the small target objects (1.35 ± 0.33) under the SMP strategy. When integrating with IC, subjects' average performances have further improved to 63.39 ± 15.38 deg, 94.22% ± 3.94%, 25.76 s ± 6.24 s and 1.05 ± 0.30 respectively, which also significantly outperformed the DP condition. These results indicated that when utilizing the deep-learning-based saliency detection and IC processing, subjects could shorten the searching process and were able to discern the target objects more reliably. This work could be informative to future prosthetic devices considering implementation with the technique of artificial intelligence.
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Oncotarget
March 2025
Worldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.
View Article and Find Full Text PDFNanomicro Lett
March 2025
Department of Mechanical Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin, Gyeonggi-do, 17104, Republic of Korea.
Many natural organisms have evolved unique sensory systems over millions of years that have allowed them to detect various changes in their surrounding environments. Sensory systems feature numerous receptors-such as photoreceptors, mechanoreceptors, and chemoreceptors-that detect various types of external stimuli, including light, pressure, vibration, sound, and chemical substances. These stimuli are converted into electrochemical signals, which are transmitted to the brain to produce the sensations of sight, touch, hearing, taste, and smell.
View Article and Find Full Text PDFAdv Mater
March 2025
Department of Biomedical Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Institute of Innovative Materials, Southern University of Science and Technology, Shenzhen, 518055, P. R. China.
The effective and precise processing of visual information by the human eye primarily relies on the diverse contrasting functions achieved through synaptic regulation of ion transport in the retina. Developing a bio-inspired retina that uses ions as information carriers can more accurately replicate retina's natural signal processing capabilities, enabling high-performance machine vision. Herein, an ion-confined transport strategy is proposed to construct a bio-inspired retina by developing artificial synapses with inhibitory and excitatory contrasting functions.
View Article and Find Full Text PDFFront Hum Neurosci
February 2025
Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology.
View Article and Find Full Text PDFPNAS Nexus
March 2025
National Academy of Engineering, Washington, DC 20001, USA.
Recent developments in artificial intelligence (AI) and machine learning (ML), driven by unprecedented data and computing capabilities, have transformed fields from computer vision to medicine, beginning to influence culture at large. These advances face key challenges: accuracy and trustworthiness issues, security vulnerabilities, algorithmic bias, lack of interpretability, and performance degradation when deployment conditions differ from training data. Fields lacking large datasets have yet to see similar impacts.
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