Accurate and efficient lung and colon cancer classification is vital for early detection and treatment planning. Traditional methods require manual effort and expert analysis, leading researchers to explore deep learning models. However, deep learning-based lung and colon cancer classification models face challenges such as generalization, overfitting, gradient vanishing, and hyperparameter tuning. To overcome these challenges, we propose an efficient Deep Attention module and a Residual block-based lung and colon cancer classification Network (DARNet). It comprises three key components such as residual blocks, attention modules, and fully connected layers. Residual blocks (RBs) are utilized to refine the DARNet's ability to learn and capture residual information which allows DARNet to perceive complex patterns and improve accuracy. Attention module (AM) enhances feature extraction and captures useful information in the input data. Finally, to achieve better generalization performance, we employ Bayesian Optimization (BO) to fine-tune the hyperparameters of DARNet. Extensive experimental results indicate that the proposed BO-based DARNet achieved superior performance over competitive models on benchmark lung and colon cancer datasets, with a median accuracy of 98.86% and lower variance.
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http://dx.doi.org/10.1109/JBHI.2024.3502636 | DOI Listing |
Med Oncol
March 2025
Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
Cancer continues to be a significant global health concern, consistently ranking as one of the leading causes of mortality across diverse populations and socio-economic contexts. Genistein, a soy-derived isoflavonoid, has gained significant attention for its diverse health benefits, particularly its potent anticancer activity. Emerging pre-clinical and clinical evidences highlights its ability to modulate key cellular processes, including apoptosis, autophagy, angiogenesis, metastasis, immune responses and cell cycle regulation.
View Article and Find Full Text PDFCancer Rep (Hoboken)
March 2025
Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Introduction: Globally, lung cancer is one of the most commonly diagnosed cancers and continues to take the lead in cancer-related mortality rates. This study aims to provide the latest statistics on the clinical, histopathological, and epidemiological features of lung cancer patients who underwent surgical resection in referral hospitals in Southern Iran.
Method: In this retrospective study, records of all patients with operable primary and secondary lung cancer who underwent surgical resection of the lung in Shiraz hospitals, located in Southern Iran from November 2009 to May 2022 were screened.
Cancer
March 2025
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Background: Oral microbes detected in feces have been associated with colorectal cancer (CRC) in cross-sectional studies. This study investigated the prospective associations between the oral microbiome and incident CRC in the Agricultural Health Study (AHS), National Institutes of Health-AARP (NIH-AARP) Diet and Health Study, and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
Methods: Individuals with oral samples collected before incident CRC diagnoses were identified in the AHS (N = 331), NIH-AARP (N = 249), and PLCO (N = 446) and compared with referent subcohorts (N = 3431).
JMIR Cancer
March 2025
Mayo Clinic College of Medicine and Science, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL, 32224, United States, 1 904-953-0853.
Background: The noninvasive imaging examinations of mammography (MG), low-dose computed tomography (CT) for lung cancer screening (LCS), and CT colonography (CTC) play important roles in screening for the most common cancer types. Internet search data can be used to gauge public interest in screening techniques, assess common screening-related questions and concerns, and formulate public awareness strategies.
Objective: This study aims to compare historical Google search volumes for MG, LCS, and CTC and to determine the most common search topics.
Despite numerous research efforts and several effective vaccines and therapies developed against COronaVIrus Disease 2019 (COVID-19), drug repurposing remains an attractive alternative to identify new treatments for SARS-CoV-2 virus variants and other viral infections that may emerge in the future. Cellular polyamines support viral propagation and tumor growth. Here we tested the antiviral activity of an irreversible inhibitor of polyamine biosynthesis, α-difluoromethylornithine (DFMO) and a non-steroidal anti-inflammatory drug (NSAID) Sulindac, which have been previously evaluated for colon cancer chemoprevention.
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